| Objective: Neurocognitive scales and resting-state Functional Magnetic Resonance Imaging(rs-f MRI)were used to explore the neurocognitive and spontaneous activity characteristics of brain regions in Successful Aging(SA).Methods: Subjects were recruited using a convenience method,between April 2019 and December 2020 at the Wuxi Mental Health Centre affiliated to Nanjing Medical University and in the community of Wuxi.After assessment by the Clinical Interview Scale and the Neurocognitive Scale,imaging data were then collected using an MRI scanner.Non-cooperators and those with unclear MRI images were excluded and included: 30 cases(11 males and 19 females)in the SA group,age range 60-79 years(69.07 ± 4.48 years).Usual Aging(UA)group 30 cases(9 males,21 females),age range 60-83 years(68.63±6.23years).The Mild Cognitive Impairment(MCI)group consisted of 24 patients(7 males and17 females),aged 60-83 years(69.25±6.93 years).The DPARSFA and SPM8 software packages were used to calculate the Kendall Consistency Coefficient(KCC)as an index of similarity to assess the similarity or synchrony between a given voxel and its nearest 26 neighbours,and KCC values were calculated for these 27 voxels.Differences in regional homogeneity(Re Ho)were compared between the three groups of subjects.Analysis of neurocognitive features and spontaneous activity characteristics of brain regions.Results: 1.Comparison of the general demographic data of the three groups revealed no statistical significance(p>0.05)in terms of gender,age,educational level,whether the children were filial,monthly income,number of children,mode of residence,duration of exercise,frequency of exercise,self-care ability,Hamilton depression,ADL scores and PSQI scores.2.Analysis of covariance by excluding age and educational level.The differences between the three groups were still statistically significant(P<0.01)in MMSE scores,Mo CA scores,total core neurological test scores and scores on eight subtests,including number breadth,rapid word formation,rapid coding,symbol matching,verbal analogy,numerical operations,picture recall and connectedness tests.A two-by-two comparison of the three groups separately revealed that the MCI group was lower than the SA and UA groups and the SA group was higher than the UA group in terms of ADA-cog scores,MMSE scores,Mo CA scores,total core neurological test scores and scores on each subtest.3.Re Ho’s analysis revealed that the three groups of subjects had a higher score on the following: right cerebellar area 9,left hippocampus,right pallidum,left pallidum,left deltoid frontal inferior gyrus,right superior temporal gyrus,right cuneus,right superior occipital gyrus,left dorsolateral superior frontal gyrus,right middle frontal gyrus,right postcentral gyrus,right precuneus and left paracentral lobule regions were statistically significant(p-value<0.05,Apha Sim corrected voxel size>18,p<0.01).Further two-by-two comparisons revealed that(1)the SA group scored significantly higher than the UA group in the left supraoccipital gyrus and left pallidum region,with statistically significant differences.(p-value <0.05,Apha Sim corrected voxel size>18,P<0.01).(2)The SA group had significantly higher Re Ho values than the MCI group in the right superior occipital gyrus,right cuneus,right middle frontal gyrus,right superior marginal gyrus,right precuneus and left paracentral lobule,and the MCI group had higher Re Ho values than the SA group in the left hippocampus,left pallidum,right pallidum,right superior temporal gyrus and left dorsolateral superior frontal gyrus,with statistically significant differences(p-value<0.05,Apha Sim corrected voxel size>18,P<0.01).(3)Re Ho values were significantly higher in the MCI group than in the UA group in left cerebellar area 10,right superior temporal gyrus,right hippocampus,left deltoid inferior frontal gyrus,right Rolando’s shell cap,and left superior limbic gyrus.Re Ho was significantly lower in the right cerebellar area 6,right cuneus and right orbitofrontal middle gyrus regions than in the UA group,with statistically significant differences(p-value<0.05,Apha Sim corrected voxel size>18,P<0.01).Conclusion: 1.The SA group maintained intact cognition and had the highest level of cognition.the MCI patients had a high degree of cognitive impairment and rapid decline.2.The SA group maintained good function of brain regions,and the MCI group had abnormal neural activity in some brain regions.3.The resting-state functional MRI local consistency study method combined with neuropsychological tests can be one of the indicators to identify MCI and predict development. |
