The Effect Of Vitamin B₁₂ Eye Drops On Corneal Sensativity And Tear Film After Corneal Refractive Surgery

Purpose:Vitamin B₁₂,as an important substance in neurometabolism,is neurophilic and has a positive effect on the repair of nerve damage.However,there is a certain degree of corneal nerve damage after corneal refractive surgery,which causes problems such as postoperative dry eyes.This study aims to confirm whether vitamin B₁₂eye drops have a positive effect on the recovery of corneal sensitivity and tear film function after corneal refractive surgery,and can shorten the recovery period,thereby providing new ideas for the treatment of dry eye after corneal refractive surgery.Methods:A total of 103 patients who underwent corneal refractive surgery at Taizhou People’s Hospital from June 2020 to December 2020 were included in this study,including 67 males and 36 females.Among them,71 were SMILE（Small incision lenticule extraction）patients（46 males,25 females）;32 FS-LASIK（Femtosecond laser-assisted in suit keratomileusis）patients（21 males and 11 females）,the average age is（21.91±4.99）years old.According to the sugery methods and postoperative drugs,the above-mentioned patients were divided into four groups:group A:SMILE（conventional group）,group B:SMILE(vitamin B₁₂eye drops group),group C:FS-LASIK（conventional group）,D Group:FS-LASIK(vitamin B₁₂eye drops group).TMH（Tear meniscus height）,NIBUT avg（Noninvasive average tear film break up time）,SIT（Schimer test I）,and corneal sensitivity examinations were performed on all patients before sugery,1 week after sugery,1 month after sugery,and 3 months after the sugery.To compare and analyze the changes over time such as TMH,NIBUT avg,SIT,and corneal sensitivity in patients with different surgical methods within 3 months after the sugery,after local routine drugs and vitamin B₁₂eye drops on the basis of routine drugs.Results:When comparing the basic data of patients before sugery,we find that there are no significant statistical differences in surgical methods,drugs,gender and age composition（P>0.05）.Comparison of the effects of drugs on related indexes before and after the surgery of the A and B groups:1).F _time=1.213,P=0.312>0.05,there is no significant statistical difference in the overall comparison of TMH between the A and B groups at different time points;F _group=2.263,P=0.089>0.05,there was no significant difference in the overall comparison of the TMH difference between the A and B groups at different time points before and after SMILE.2).F _time=7.770,P=0.000<0.05,the overall comparison of NIBUT avg at different time points between groups A and B,there is a significant statistical difference;F _group=0.320,P=0.811>0.05,there was no statistically significant difference in NIBUT avg difference between A and B at different time points before and after SMILE.3).F _time=19.300,P=0.000<0.05,there are significant statistical differences in the overall comparison of SIT between A and B groups at different time points;F _group=1.840,P=0.148>0.05,there was no statistically significant difference in the SIT difference between the two groups at time points A and B at different before and after SMILE.4).F _time=3.580,P=0.018<0.05,the overall comparison of corneal sensativity between A and B groups at different time points,there is a significant statistical difference;F _group=66.535,P=0.000<0.05,at different time points,group B can better improve corneal sensativity than group A before and after SMILE,and there are significant statistical differences.The recovery speed of group B was faster than that of group A.Comparison of the effects of drugs on related indexes before and after surgery in the C and D groups:1).F _time=0.851,P=0.470>0.05,there is no significant statistical difference in the overall comparison of TMH between the C and D groups at different time points;F _group=2.708,P=0.050=0.05,There was no statistically significant difference in the difference between the two groups of TMH at points C and D at different time before and after FS-LASIK.2).F _time=2.949,P=0.037<0.05,the overall comparison of NIBUT avg between the C and D groups at different time points,there is a significant statistical difference;F group=1.914,P=0.129>0.05,There was no significant difference in NIBUT avg between C and D at different time points before and after the FS-LASIK.3).F _time=1.330,P=0.270>0.05,there is no significant statistical difference in the overall comparison of SIT between the C and D groups at different time points;F _group=0.772,P=0.512>0.05,There was no statistically significant difference in the SIT difference between the C and D groups at different time points before and after FS-LASIK.4).F _time=75.912,P=0.000<0.05,the overall comparison of corneal sensativity between C and D groups at different time points,there is a significant statistical difference;F _group=3.964,P=0.018<0.05,group D can better improve corneal sensativity than group C at different time points before and after the FS-LASIK,and there are significant statistical differences.Group D has a faster recovery rate than group C.Conclusion:Compared with preoperatively,NIBUT avg,SIT,and corneal sensativity decreased to a certain extent after SMILE and FS-LASIK.Vitamin B₁₂eye drops can improve corneal sensativity after SMILE and FS-LASIK.Vitamin B₁₂eye drops have no obvious improvement effect on TMH,NIBUT avg and SIT after SMILE and FS-LASIK.