Analysis Of Clinical Differences In Parkinson’s Disease With And Without Excessive Daytime Sleepiness

Purpose:With the gradual deepening of research on the diagnosis and prevention of Parkinson’s disease-related sleep disorders,PD-related sleep disorders have begun to receive widespread attention from more and more patients and medical staff.Among them,EDS is the most current development of PD patients A common type of sleep disorder,the patients account for about 15%-74%,and it is one of the main factors that seriously endanger the health of Parkinson’s disease patients.The most important clinical feature of EDS is that it is easy to fall asleep again quickly when awake during the day,and it is difficult to stay alert,which has a negative impact on the quality of life,concentration,memory and judgment,and may lead to cognitive impairment.Some studies have shown that EDS,as a special clinical manifestation of PD patients,can provide a reference for studying the progression of the disease,but there are still many doubts between EDS and PD,and the results of different studies are also different.Therefore,we collected past cross-sectional studies of the clinical manifestations of PD patients with and without excessive daytime sleepiness,compared the relevant factors of the existing clinical differences,performed meta-analysis,and systematically evaluated Parkinson’s disease patients with and without excessive daytime sleepiness The differences in clinical manifestations facilitate clinical diagnosis and treatment,and provide references for scientific research.Method:Use "excessive daytime sleepiness",EDS,"Parkinson disease",PD,"factors" and risk factors,related factors,as the main English keywords,and use "Parkinson’s disease" and " "Excessive daytime sleepiness" is a Chinese search term.Search Wanfang database,CNKI and other related Chinese databases,Pubmed,Cochrance,Web of Science and other related English databases,and select references by consulting and tracking other related documents A cross-sectional research report on the relationship between excessive daytime sleepiness and Parkinson’s disease was published from January 1,2000 to December 31,2020.According to the quality evaluation standards for cross-sectional studies provided by the American Agency for Health Care Research and Quality(AHRQ),the literature is evaluated and screened to meet the requirements,and Stata 14.2 is used for heterogeneity testing,sensitivity and publication bias analysis.Results:A total of 11 cross-sectional studies were included.There were a total of 5813 patients with Parkinson’s disease,of which 1128 patients were in the EDS-PD group and 4685 patients were not in the EDS-PD(no EDS-PD)group.Meta-analysis suggests that compared with PD without EDS,PD with EDS suffers from a greater age(WMD=1.88;95% CI: 0.49-3.27;P = 0.008)and a larger dose of levodopa(WMD = 40.36;95% CI: 10.5 to 70.22;P = 0.008),longer duration of disease(WMD= 1.46;95% CI: 0.38 to 2.53;P = 0.008),lower MMSE score(WMD =-0.88;95% CI:-1.48 to-0.29;P = 0.004),while the Hoehn-Yahr grading indicated that there was little difference between groups(WMD = 0.16;95% CI:-0.11 to 0.43;P = 0.250).Conclusion:Compared with PD,PD patients with EDS are older,have longer disease duration,use more levodopa drugs,have lower MMSE scores,and have severe cognitive impairment;Hoehn-Yahr grading factor analysis showed no significant difference in this study.