| Objective:To investigate the expression of DNA mismatch repair protein in patients with endometrial carcinoma,to compare and analyze the different characteristics of loss of MMR protein expression and normal expression in endometrial carcinoma,and to explore the correlation and clinical significance between clinicopathological features and MMR protein expression in endometrial carcinoma.Methods:A retrospective analysis was made of 272 patients with endometrial carcinoma who were newly diagnosed and underwent staged surgery in the affiliated Cancer Hospital of Xinjiang Medical University from January 2019 to July 2020.The expression of four kinds of MMR protein in tumor tissue was detected by immunohistochemical method.Chi-square test and Logistic regression were used to analyze the relationship between MMR protein expression and clinicopathological features of endometrial carcinoma.Results : The expression of MMR protein was absent in 55 of 272 patients with endometrial carcinoma,accounting for 20.2%.The single deletion rates of MLH1,MSH2,MSH6 and PMS2 were2.2%(6 cases),1.5%(4 cases),2.5%(7 cases)and 1.5%(4 cases),respectively.The common deletion rates of MLH1/ PMS2,MSH2/MSH6 and MLH1/MSH2 were 9.5%(26 cases),2.2%(6 cases)and 0.4%(1 case),respectively,and the common deletion rate of MSH2/MSH6/PMS2 was 0.4%(1 case).Univariate analysis showed that the loss of MMR protein expression was associated with BMI,tissue grade,myometrial invasion,vascular invasion and tumor location,but not with age of onset,FIGO stage,histological type,tumor size,lymph node metastasis,ascites,personal and family history of malignant tumor(P> 0.05).Multivariate analysis showed that MMR protein expression loss was more likely to occur in endometrial carcinoma with low BMI,high histological grade,deep myometrial invasion,vascular invasion and tumor invasion of the lower segment of the uterine body.Conclusion:The histological type of endometrial carcinoma with loss of MMR protein expression is endometrioid adenocarcinoma.The correlation between clinicopathological parameters showed that the cases of endometrial carcinoma with loss of MMR protein expression and normal expression had different clinicopathological features.The loss of MMR protein expression was characterizedby low BMI,high histological grade,deep myometrial invasion,positive vascular thrombus and easy to invade the lower segment of the uterine body. |
