Study On The Relationship Of Serum Lp(a),Hcy,UA Levels With Acute Ischemic Stroke In Young People

Objective: To explore the relationship between the levels of blood lipoprotein a,homocysteine,uric acid and acute ischemic stroke in young people.Method: Using retrospective research methods,316 young patients with acute ischemic stroke who were hospitalized in the Department of Neurology of the First Affiliated Hospital of Xinjiang Medical University from July 2016 to December 2020 were selected as the case group according to the inclusion and exclusion criteria.637 young non-ischemic stroke patients who were hospitalized during the same period were selected as the control group.Collect clinical,laboratory and imaging data of all research subjects,analyze the distribution characteristics of blood lipoprotein a,homocysteine,and uric acid concentrations in the two groups of patients;compare the basic information,clinical data,and laboratory between the two groups of patients Differences in indicators;single-factor and multi-factor logistic regression analysis methods are used to explore the relationship between blood lipoprotein a,homocysteine,uric acid levels and the occurrence of acute ischemic stroke in young people.Results: Male in the case group,body mass index,smoking history,drinking history,high blood pressure,diabetes,valvular heart disease,other heart diseases,triglycerides,apolipoprotein B,lipoprotein a,homocysteine,uric acid,white blood cells The level was higher than that of the control group,and the difference was statistically significant(P<0.05);the levels of HDL cholesterol and apolipoprotein AⅠ in the case group were lower than those of the control group,and the difference was statistically significant(P<0.05);There was no significant difference in age,atrial fibrillation,patent foramen ovale,total cholesterol,and low-density lipoprotein cholesterol levels(P>0.05).The natural logarithm of blood lipoprotein a concentration to the risk of acute ischemic stroke in young adults was 1.630(95%CI=1.362～1.952,P<0.001).The risk of acute ischemic stroke for young men and young women was 1.596(95%CI=1.306 ～ 1.950,P < 0.001)and 1.599(95%CI=1.055 ～ 2.425,P=0.027),respectively.The natural logarithm of blood homocysteine concentration to the risk of acute ischemic stroke in young adults was 3.740(95%CI=2.438～5.740,P<0.001).The risk of acute ischemic stroke in young men was 4.169(95%CI= 2.574～6.752,P<0.001),and there was no statistically significant difference in the risk of acute ischemic stroke in young women(P>0.05).The risk of blood uric acid concentration in young adults with acute ischemic stroke was 1.003(95%CI=1.001 ～ 1.005,P=0.004).The risk of acute ischemic stroke for young men and young women was 1.003(95%CI=1.000 ～ 1.006,P=0.036)and 1.007(95%CI=1.000～1.013,P=0.044).Conclusion:(1)Elevated levels of lipoprotein a is one of the independent risk factors for the occurrence of acute ischemic stroke in young people.The higher the plasma level,the greater the risk of acute ischemic stroke in young men;the risk is not significant among young women.(2)The elevated blood homocysteine level is one of the independent risk factors for the occurrence of acute ischemic stroke in young men.The higher the plasma level,the greater the risk of acute ischemic stroke in young men.No association has been found between elevated blood homocysteine levels and the occurrence of acute ischemic stroke in young women.(3)Elevated blood uric acid level is one of the independent risk factors for acute ischemic stroke in young people.The higher the plasma level,the greater the risk of acute ischemic stroke in young women;the risk is not significant among young men.