Analysis Of The Changes Of Serum 11 Minerals In Children With Febrile Convulsion

ObjectiveBy analyzing the changes of serum 11 minerals in children with febrile seizures,to explore the correlation between febrile seizures and serum 11 minerals,and to provide new ideas for the diagnosis,treatment and prevention of children with febrile seizures.MethodsSelect 40 children diagnosed with febrile seizures in our hospital from October 2019 to November 2020 and meet the inclusion criteria as the febrile seizure group(group A),and randomly select 40 children with upper respiratory tract infection as the upper respiratory tract during the same period The infection group(group B)and 40 children with normal physical examinations in this hospital belong to the healthy children group(group C).Serum calcium(Ca),iron(Fe),zinc(Zn),magnesium(Mg),copper(Cu),manganese(Mn),selenium(Se),mercury(Hg),nickel(Ni)in the three groups of children The content of cobalt(Co)and lithium(Li)was determined by inductively coupled plasma mass spectrometry.The collected data are statistically analyzed using SPSS22.0 software.Normally distributed measurement data are represented by mean ± standard deviation(x±s),and non-normally distributed measurement data are represented by median and interquartile range [M(P25,P75)].The χ2 test was used to compare the gender composition of different groups.The comparison of each index among the three groups adopts analysis of variance(F test)or Kruskal-Wallis H test.Binomial logistic regression analysis was used for multivariate analysis.Results1.The three groups of children’s serum zinc,magnesium,and selenium showed normal distribution,and met the homogeneity of variance,so the F test was used.The results showed that the serum zinc level in the febrile seizure group was the lowest,followed by the upper respiratory tract infection group,and the healthy child group was the highest.The difference was statistically significant(F=18.703,P<0.05);the febrile seizure group,upper respiratory tract infection group and healthy children There was no significant difference in serum magnesium levels between the two groups(F=1.811,P>0.05);there was no significant difference in serum selenium between the febrile seizure group,upper respiratory tract infection group,and the healthy child group(F=0.919,P>0.05).2.Serum calcium,iron,copper,manganese,mercury,nickel,cobalt,and lithium of the three groups of children showed non-normal distribution or did not meet the homogeneity of variance,so the Kruskal-Wallis H test was used.The results showed that the serum calcium,copper,manganese,and mercury levels of the febrile seizure group,the upper respiratory tract infection group and the normal child group were significantly different(P<0.05);the febrile seizure group,the upper respiratory tract infection group and the normal group were significantly different There was no significant difference in serum iron,nickel,cobalt,and lithium in the child group(P>0.05).3.This study showed that there may be a certain correlation between serum zinc,calcium,copper,manganese,mercury and the occurrence of febrile seizures in children.After binomial logistic regression analysis,the difference in calcium levels was not statistically significant(P>0.05).The difference in zinc levels was statistically significant(P<0.05).There was a negative correlation between zinc and febrile seizures,and low zinc was a risk factor for febrile seizures.The difference in copper levels was statistically significant(P<0.05).There was a positive correlation between copper and febrile seizures,and high copper was a risk factor for febrile seizures.The difference in manganese levels was statistically significant(P<0.05).Manganese was positively correlated with febrile seizures,and high manganese was a risk factor for febrile seizures.The difference in mercury levels was statistically significant(P<0.05).There was a positive correlation between mercury and febrile seizures,and high mercury was a risk factor for febrile seizures.Conclusion1.Serum zinc is closely related to febrile seizures.Children with febrile seizures are prone to lower serum zinc levels.This suggests that in the clinical diagnosis and treatment of children with febrile seizures,attention should be paid to the changes in serum zinc in children,and if abnormalities are found,they should be corrected in time,This may reduce the occurrence of febrile seizures,which is conducive to the recovery of the disease in children.2.Elevated serum manganese and mercury may play a certain role in the occurrence of febrile seizures.Clinically,children with febrile seizures should avoid eating foods containing manganese and mercury.