| ObjectivePatients with Qi-deficiency syndrome(Qi-deficiency syndrome)were taken as the research objects,and healthy people were used as controls to observe the effects of different acupuncture and moxibustion therapies on the mean heart rate(mean HR)and heart rate variability(Heart Rate Variability)of patients with Qi-deficiency syndrome.,HRV)related indicators of the diagnosis and treatment effect and the impact on the syndrome score,including total heart rate variability(total heart rate variability,HRV total),all sinus heart rate RR interval(referred to as the NN interval)standard deviation(Standard Diviation)of NN intervals,SDNN),the root mean square of difference between adjacent NN intervals,r-MSSD within 24 h,Very Low Frequency(VLF),Low Frequency(LF),High Frequency(HF),Log(Low Frequency/High Frequency),log(LF/HF)).To explore the difference in HRV between patients with Qi deficiency syndrome and healthy people,to study the effects and mechanisms of different single-point acupuncture,to compare the compatibility of Zusanli and Guanyuan acupoints and the differences in the efficacy of single-point application and the differences in HR/HRV indicators,and to clarify the double-point acupuncture The regulation mechanism of the effects of acupoints and moxibustion on patients with Qi-deficiency syndrome is compared with the difference in curative effect between acupuncture and fake acupuncture on patients with Qi-deficiency syndrome.MethodsIn the Huangjiahu Hospital of Hubei University of Traditional Chinese Medicine and the Affiliated Traditional Chinese Medicine Hall,75 patients who met the trial inclusion criteria were divided into acupuncture double-point group(15 cases),moxibustion group(15 cases),and moxibustion group(15 cases)according to the random number table.Acupuncture Zusanli group(15 cases),acupuncture Guanyuan group(15 cases),and sham acupuncture group(15 cases).In addition,recruit healthy volunteers(15 cases),and then conduct research with traditional medicine at Graz Medical University in Austria The center conducts collaborative analysis.In experiment 1,the patients with Qi-deficiency syndrome and healthy subjects included in the trial filled out the Qi-deficiency score scale,and the HRV was measured for 45 minutes in all patients with Qi-deficiency syndrome and healthy subjects in a calm state.Experiment two,acupuncture at both Zusanli and Guanyuan points,acupuncture at the double-point group(acupuncture at Guanyuan and bilateral Zusanli),acupuncture at the Zusanli group(acupuncture at both sides of Zusanli,sham acupuncture at Guanyuan),Acupuncture in the Guanyuan group(acupuncture at Guanyuan,sham acupuncture on both sides of Zusanli)and sham acupuncture group(sham acupuncture at Guanyuan,on both sides of Zusanli)is acupuncture once every other day,every 15 minutes,every 5Acupuncture was performed once every minute;in the moxibustion group(Guanyuan moxibustion,Zusanli on both sides)every other day,moxibustion was performed every 15 minutes,ten times;before the first treatment,after the fourth treatment,and the tenth After the first treatment,the patient’s Qi Deficiency Scale score was recorded.HRV was tested for the entire course of the first treatment,and HRV was measured again for 45 minutes in a calm state after the fourth and tenth treatments.The measuring instrument adopts HRVMedilog AR12 provided by the Traditional Medicine Research Center of Graz Medical University.It is connected to the chest wall skin of the subject through three skin electrodes.The ECG signals of the three groups of subjects are collected and the data is sent back to the Traditional Medicine of Graz Medical University.The research center analyzes and obtains data feedback on HRV related indicators.Results1.The score of Qi Deficiency Scale for patients with Qi Deficiency Syndrome was significantly higher than that of healthy subjects(P<0.01),Mean HR,HRV total,SDNN,r-MSSD,VLF,LF,HF,log(LF/HF)in a calm state There was no statistical difference(P>0.05).2.After treatment,the total HRV,SDNN and LF of the Zusanli acupuncture group increased,which were statistically different from before treatment(P<0.05).Mean HR,r-MSSD,VLF,HF,log(LF/HF)increased,But not statistically different from before treatment(P>0.05);mean HR,VLF,LF,log(LF/HF)decreased,total HRV,SDNN,r-MSSD,HF increased,but with treatment There was no statistical difference compared with the previous(P>0.05).Compared with acupuncture Zusanli group after treatment,HRV total,SDNN,r-MSSD,LF increased,there was a statistical difference(P<0.05),Mean HR,VLF,HF increased,log(LF/ HF)decreased,but there was no statistical difference compared with before treatment(P>0.05);Compared with the acupuncture double-point group and the Guanyuan group after treatment,Mean HR increased,there was a statistical difference(P<0.05),HRV total,SDNN,r-MSSD,VLF,LF,HF increased,log(LF/HF)decreased,but there was no statistical difference compared with before treatment(P>0.05);acupuncture Zusanli group and acupuncture Guanyuan After treatment,Mean HR,HRV total,SDNN,r-MSSD,VLF,LF,HF,log(LF/HF)increased,but there was no statistical difference compared with before treatment(P>0.05).3.After treatment,the HRV total,SDNN,r-MSSD,and VLF in the double-point acupuncture group increased,which were statistically different from those before treatment(P<0.05);Mean HR,log(LF/HF)decreased,LF,HF Increased,but there was no statistical difference compared with before treatment(P>0.05);mean HR decreased,HRV total and VLF increased in moxibustion group,and there were statistical differences compared with before treatment(P<0.05);SDNN,r-MSSD,LF,HF increased,log(LF/HF)decreased,but there was no statistical difference compared with before treatment(P>0.05).Compared with the results of the moxibustion group after acupuncture treatment,Mean HR,HRV total,SDNN,r-MSSD,VLF,LF,HF increased,log(LF/HF)decreased,but there was no statistical difference(P >0.05).4.Compared with the results of the sham acupuncture group,the log(LF/HF)increased in the double-point acupuncture group and the sham acupuncture group,which was statistically different from before treatment(P<0.05);Mean HR,HRV total,SDNN,r-MSSD,VLF,LF,HF all increased,but there was no statistical difference(P>0.05).After the first treatment,LF increased significantly,with statistical significance(P<0.05),Mean HR,HRV total,SDNN,r-MSSD,VLF,HF,log(LF/HF)all increased,but not Statistical significance(P>0.05);after the fourth treatment,SDNN and LF increased,with statistical significance(P<0.05),Mean HR,HRV total,r-MSSD,VLF,HF,log(LF/ HF)increased,but not statistically significant(P>0.05);after the tenth treatment,log(LF/HF)increased,statistically significant(P<0.05),Mean HR,HRV total,SDNN,R-MSSD,VLF,LF all increased,HF decreased,but not statistically significant(P>0.05).5.Compared with before treatment,the scores of the five groups of Qi Deficiency Scale were significantly reduced after treatment(P<0.05);there was no significant difference between the five groups(P>0.05).Conclusion1.The score of Qi Deficiency Scale for patients with Qi Deficiency Syndrome was significantly higher than that of healthy subjects,and there was no significant difference in mean HR and HRV related indicators.2.Acupuncture at double acupoints and single acupoints has different therapeutic effects on patients with mean HR and HRV.After treatment,acupuncture at double points caused a significant increase in the patient’s HRV total,SDNN,r-MSSD,and VLF.Acupuncture at Zusanli caused an increase in the patient’s HRV total,SDNN,and LF.Acupuncture at Guanyuan showed no obvious specificity.The effect of acupuncture at double points in improving HRV total,SDNN,r-MSSD and LF is significantly better than acupuncture at Zusanli single point.Double-point acupuncture is better than single-point Guanyuan acupuncture in improving the patient’s Mean HR.The effect of acupuncture at Zusanli and acupuncture at Guanyuan is temporarily not obvious.3.Acupuncture and moxibustion have different therapeutic effects.After the intervention of the two treatment methods,the mean HR and HRV related indexes of patients with Qi deficiency syndrome changed significantly compared with the previous ones.HRV total and VLF both showed an upward trend in the two groups.Acupuncture and moxibustion may have the therapeutic effect of increasing HRV total and VLF.Acupuncture at double acupoints caused a significant increase in the patient’s HRV total,SDNN,r-MSSD,and VLF.Moxibustion caused a decrease in the patient’s mean HR,and an increase in HRV total and VLF.Acupuncture and moxibustion may have different control over sympathetic and parasympathetic nerves.Therapeutic effect.4.The effect of acupuncture and fake acupuncture is not obvious under the sample size,but the phased treatment shows a trend of obvious effect difference.Only log(LF/HF)has significant difference between the two groups after treatment,but after the first treatment,it can cause the patient’s LF to rise,and after the fourth treatment,it can cause the patient’s SDNN and LF to rise,suggesting acupuncture Acupuncture may be closely related to the activity of sympathetic nerves in staged treatment.5.Different acupuncture and moxibustion therapies can significantly improve the clinical symptoms of patients with Qi-deficiency syndrome,but with the current sample size,several treatment measures have not yet shown significant differences. |
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