Study On Clinical Effect Of Traditional Chinese Medicine On Acute On Chronic Liver Failure

Objective: To explore the clinical effect of traditional Chinese medicine on acute-on-chronic liver failure(ACLF)and the effect on survival rate of ACLF patients.Methods: 1.Retrospective study was used in clinical research.The patients diagnosed as acute-on-chronic liver failure from January 2018 to December 2020 of Hubei Provincial Hospital of traditional Chinese medicine were selected.21 cases who had never used TCM treatment method in the treatment were selected as control group.44 cases were selected as observation group,and the control group was after admission.The observation group was given the corresponding Chinese medicine treatment according to the syndrome differentiation of traditional Chinese medicine on the basis of the conventional basic treatment plan.2.The first laboratory indexes before admission were baseline(i.e.pre treatment indicators),and the related clinical symptoms,liver function indexes(alt,AST,ALB,TBIL),coagulation function index(PTA),blood routine correlation index(WBC,NLR,PLT),renal function index(Cr,Na),TCM Syndrome score and calculation were recorded respectively at the second,fourth,8th and 12th weeks after treatment The above indexes were compared statistically between the two groups after treatment.Results:(1)at the 8th week after treatment,the mortality rate of the treatment group was 15.9% and 47.6% in the treatment group,which was statistically significant(P < 0.05).The total effective rate of the treatment group was 61.36% and 33.33% in the control group at the 12th week after treatment.The difference was statistically significant(P < 0.05).(2)The TBIL level of the treatment group and the control group were significantly improved at the 4th and 8th weeks after treatment,and the decrease of TBIL in the treatment group was better than that of the control group.The difference between the two groups was statistically significant(P <0.05).(3)The PTA level of the treatment group was significantly increased at the 8th week after treatment.Compared with the western medicine treatment group,the difference was statistically significant(P < 0.05).The intervention of traditional Chinese medicine for ACLF could improve the coagulation function of patients more effectively than the comprehensive treatment of Western medicine.(4)At the fourth week after treatment,ALT and AST of the two groups decreased significantly,ALT and AST in the treatment group were significantly lower than that of the control group,and the difference of ALT and AST between the two groups was statistically significant(P < 0.05).(5)The neutrophil / lymphocyte ratio(NLR)of the two groups decreased.At the 12th week after treatment,the difference between the treatment group and the control group was statistically significant(P < 0.05).(6)CR of the two groups decreased significantly after treatment.At the fourth week after treatment,the serum creatinine levels were significantly different between the two groups(P < 0.05).(7)At the 12th week after treatment,Na of the two groups increased significantly,and the difference between the two groups was statistically significant.(8)The results showed that the TCM syndrome score of the two groups decreased significantly after treatment.In the second and fourth weeks after treatment,the difference was statistically significant(P < 0.05).(9)The results showed that the MELD score of the two groups decreased significantly.At the 8th and 12th weeks of the second week and fourth week after treatment,the difference was statistically significant(P < 0.01)between the treatment group and the control group(P < 0.01).Conclusion: the combination of Chinese and Western medicine can significantly reduce the short-term(8 weeks)fatality rate,and the intervention of traditional Chinese medicine can effectively improve the total effective rate of patients with chronic liver failure,and also improve the symptoms of patients.The improvement of alt,AST,TBIL,PTA,NLR,Cr,Na,MELD and TCM syndrome score in the treatment group is significantly better than that of the control group.There is no significant difference between the WBC and PLT levels between the two groups.