Evaluation Of Child-Pugh Classification In Patients With Liver Cirrhosis Using T1 Mapping Technique

Purpose:To apply T1 mapping method for measurement of the liver T1 values in patients with liver cirrhosis and to evaluate the Child-Pugh classification in patients with liver cirrhosis.Methods:This study is a prospective study and included 81 patients who underwent abdominal MRI(3T)examination from August 2019 to March 2020,including 57 patients with cirrhosis and 24 healthy people without chronic liver disease.We Applied T1 mapping technique to perform liver MRI scan of the patient using an improved Look-Locker sequence.A reader performed the measurement of 3 circular ROIs on the liver T1 maps.Statistical analysis were used to compare the differences in T1 between each group.Results:The T1 values of healthy subjects and Child-Pugh A,B,and C cirrhosis patients were:885.88±41.52,957.64±64.38 ms,987.03±73.95 ms,1114.79±249.18 ms respectively.There is a significant difference in T1 values between healthy people and patients in the cirrhosis group.There was a continuous increase in T1 values from Child-Pugh A to C(Child-Pugh A:957.64±64.38 ms;Child-Pugh B:987.03±73.95 ms;Child-Pugh C:1114.79±249.18 ms).There are significant differences between Child-Pugh A,Child-Pugh C.Significant difference between Child-Pugh B,Child-Pugh C(Child-Pugh A:C,p=0.003;Child-Pugh B:C,p=0.026)was observed.There was no significant difference between Child-Pugh A and Child-Pugh B(p=0.64).Conclusion:There was a difference in T1 relaxation times between Child-Pugh classification groups in patients with liver cirrhosis.Therefore,T1 mapping technique can quantitatively evaluate the liver function of patients with liver cirrhosis.