Study On Surface Modification Of Dental Implant Material Polyether-Ether-Ketone

Background:PEEK material is superior to traditional implant materials in terms of elastic modulus close to cortical bone,radiation permeability and chemical corrosion resistance.However,its hydrophobic surface inhibits peripheral osteogenesis,resulting in a lack of effective connection between the material and the surrounding tissue,which reduces the initial stability after implantation.After modification of the material,it was found that the surface topography of the rough or porous structure effectively promoted the osseointegration ability of the material.In this paper,the osteogenic principle and processing method of surface topography were analyzed through systematic review,and then the material was modified through experiments.Through processing,the material can maintain the original mechanical properties and form the surface topography with biological activity,so as to improve its osseogenesis ability.Purpose:1.To systematically summarize the osteogenic function and processing methods of the surface topography of different sizes,in order to promote the research on the surface topography related issues of the material.2.Through the porous structure of rough processing,and to explore the structure and verify whether they improve hydrophilic material,impact on the material mechanical properties,whether can be used as surface topography is applied to implant materials.Methods:1.A systematic review was carried out,and PubMed/Medicine and Web of Science databases were searched to summarize the osteogenic functions of surface morphology in different size ranges,and the rough or porous structures of PEEK materials generated by different processing methods were compared.2.In the experiment,the melt deposition manufacturing method is adopted to conduct primary processing on the material to form customized porous structure.Scanning electron microscopy was used to characterize the porous structure.The initial processed samples were divided into two groups.The experimental group was sulfonated with concentrated sulfuric acid to form a rough porous structure,and then rinsed and immersed in NaOH to remove the residual acid on the surface.The control group did not do any treatment.3D laser microscope was used to compare and analyze the roughness of the side walls of the two groups of holes,water contact Angle test was used to analyze the hydrophilicity,and compression test was used to compare the compression strength of the two groups.In order to further study the effect of pore size parameters of porous structure on osseointegration,the possibility of using this structure as the surface topography of the implant was comprehensively analyzed.Results:1.Different surface forms have different osteogenic principles,so the processing technology can be improved and different size forms can be formed on the surface of the material to promote the bone bonding of the material.There are many processing methods for PEEK material to realize rough or porous structure,and the surface topography of PEEK material generated by different processing methods varies in different size range.2.After initial processing,the material is rectangular porous structure:the hole shape is square;High interconnection between holes;The aperture is between 50 and 150um.After sulfonation,the lateral wall of the pores in the experimental group was rougher than that in the control group,and the hydrophilicity was significantly improved,but the compression strength did not change,which confirmed that the rough porous structure could be used as the surface topography of the implants and could be used for further biological research.Conclusion:1.Surface topography performs different functions in different size ranges,but the specific parameters on osseogenesis are still controversial.There are a variety of processing methods for surface topography,but in different processing,parameters such as roughness and hole topography cannot be effectively controlled,which limits the study on PEEK osteointegration.2.Through the way of fused deposition manufacturing processing PEEK,formed the porous structure.It was sulfonated with concentrated sulfuric acid,rinsed and immersed in NaOH to effectively remove the residual acid.The compression strength of PEEK after treatment remained unchanged,but its hydrophilicity was significantly enhanced,which further promoted the application of PEEK in implant materials.