| Objective By analyzing the relationship between Cerebral Watershed Infarction(CWI)of Qi deficiency and blood stasis syndrome and the degree of intracranial and extracranial vascular stenosis,the properties of carotid plaque and the intervention effect of Yiqi Huoxue Decoction,this paper discusses the clinical characteristics of CWI of Qi deficiency and blood stasis syndrome,evaluates the clinical efficacy and safety of Yiqi Huoxue Decoction,and provides the corresponding theoretical basis for the prevention and therapy of CWI.Methods 1.According to the Bogousslavsky classification,the degree of intracranial and extracranial vascular stenosis and the properties of carotid plaque in different types of CWI were analyzed.2.A total of 60 patients were randomly divided into experimental group and control group,30 in each group.Both groups received conventional therapy,and the experimental group was further treated with Yiqi Huoxue Decoction.The changes of TCM syndrome score,NIHSS score,Barthel index,hs CRP,Hcy,UA and related safety indexes were observed before and after therapy.Results 1.Of the 60 cases,18 were CWSI(30.0%),30 were IWSI(50.0%)and 12 were MWSI(20.0%).Most of the patients were moderate or severe stenosis or occlusion of MCA(68.3%),followed by ICA(50.0%).The patients in CWSI group were mainly moderate or severe stenosis or occlusion of ICA(61.1%)and IWSI groups were mainly moderate or severe stenosis or occlusion of MCA(80.0%),MWSI groups were mainly moderate or severe stenosis or occlusion of MCA(75.0%).And the CWSI group had the most unstable plaques(83.3%),there was significant difference between the IWSI group and the CWSI group(P<0.05).2.After therapy,the scores of TCM syndromes in both groups were lower(P<0.01).Compared with the control group,the TCM syndrome score in the experimental group decreased significantly(P<0.05).The effective rate was 66.67%in the experimental group and 40.00%in the control group,the results were statistically significant(P<0.05).3.The NIHSS scores of both groups were lower after therapy(P<0.01),the results between the groups were significant differences(P<0.05).The effective rate of NIHSS was 86.67%in the experimental group and 76.67%in the control group,the results were statistically significant(P<0.05).4.In terms of Barthel index,patients in both groups increased after therapy(P<0.01).The daily living ability in the experimental group was greatly increased compared with the control group(P<0.05).5.The levels of hs-CRP,Hey and UA in both groups decreased after therapy(P<0.01).The results were significantly decreased in the experimental group compared with the control group(P<0.01 or P<0.05).6.According to the safety analysis,there was no adverse reaction,no abnormality of liver,kidney and coagulation function and no obvious change of electrocardiogram before and after therapy.Conclusions 1.Different types of CWI have different characteristics of intracranial and extracranial vascular stenosis and carotid plaque.Moderate and severe stenosis or occlusion of MCA occurs mainly in IWSI,unstable plaques occurs mainly in CWSI.2.Yiqi Huoxue Decoction can significantly improve hs-CRP,Hcy and UA levels and clinical symptoms in patients,and has certain safety. |
