A Comparative Study Of Traditional Chinese Medicine Syndrome Elements Between Newly Diagnosed Indolent And Aggressive B-cell Non-hodgkin’s Lymphomas

ObjectiveTo investigate the distribution of traditional Chinese medicine syndrome elements in newly diagnosed B-cell non-Hodgkin’s lymphomas,and compare the differences between indolent and aggressive B-cell non-Hodgkin’s lymphoma.The purpose is to provide a theoretical basis for TCM syndrome differentiation and treatment of non-Hodgkin’s lymphomas.MethodsThis study collected 110 cases of patients from April 2019 to January 2020 with newly diagnosed B-cell non-Hodgkin’s lymphomas,aged 14 to 85,combined with Guangdong Hospital of TCM,the First Affiliated Hospital of Guangzhou University of TCM,the Guangzhou Hospital of TCM.The informations were entered into Excel 2007 to establish a database.The SPSS 17.0 software was used for frequency statistic,analysis of difference,cluster analysis,to further generalize the distribution of traditional Chinese medicine syndrome elements in B-cell non-Hodgkin’s lymphomas and find out the differences between indolent and aggressive B-cell non-Hodgkin’s lymphoma.Results(1)The distribution of syndrome elements in B-cell non-Hodgkin’s lymphoma:Disease location:spleen ranks first and kidney is second,there is statistical difference compared with each other(P<0.05);Stomach ranks last.Disease characteristics:Qi deficiency and phlegm are on the top,there is statistical difference compared with other syndrome elements of disease characteristics(P<0.05);Dampness and yang deficiency are second;There is no statistical difference compared with blood stasis,yin deficiency and qi stagnation(P>0.05),so as toxin and blood deficiency(P>0.05);Blood heat ranks last.(2)Spleen,yang deficiency,dampness and cold are relatively common in indolent B-cell non-Hodgkin’s lymphoma(P<0.05);Lung,yin deficiency,blood stasis,toxin,heat and blood heat are relatively common in aggressive B-cell non-Hodgkin’s lymphoma(P<0.05);Kidney,liver,qi deficiency,phlegm,blood deficiency and qi stagnation are similar in two groups(P>0.05).(3)The main pathogenesis of indolent B-cell non-Hodgkin’s lymphoma is spleen kidney yang deficiency,qi deficiency and phlegm obstruction,endogenous cold and dampness,conditionally combined with the stagnation of liver qi,yin blood deficiency,toxin and blood stasis,etc.The main pathogenesis of aggressive B-cell non-Hodgkin’s lymphoma is deficiency of lung,spleen and kidney,integration of phlegm dampness,heat toxin and blood stasis,conditionally combined with the stagnation of liver qi.ConclusionThe TCM syndrome characteristics of B-cell non-Hodgkin’s lymphoma is intermingled deficiency and excess.The main syndrome elements of disease location are spleen and kidney,involving lung and liver.The main syndrome elements of disease characteristics are qi deficiency,phlegm,dampness and yang deficiency,involing qi stagnation,blood stasis,blood deficiency,yin deficiency and toxin,ect.Spleen,yang deficiency,dampness and cold are relatively common in indolent B-cell non-Hodgkin’s lymphoma;Lung,yin deficiency,blood stasis,toxin,heat and blood heat are relatively common in aggressive B-cell non-Hodgkin’s lymphoma;Kidney,liver,qi deficiency,phlegm,blood deficiency and qi stagnation are similar in two groups.The main pathogenesis of indolent B-cell non-Hodgkin’s lymphoma is spleen kidney yang deficiency,qi deficiency and phlegm obstruction,endogenous cold and dampness,conditionally combined with the stagnation of liver qi,yin blood deficiency,toxin and blood stasis,etc.The main pathogenesis of aggressive B-cell non-Hodgkin’s lymphoma is deficiency of lung,spleen and kidney,integration of phlegm dampness,heat toxin and blood stasis,conditionally combined with the stagnation of liver qi.