| ObjectiveBuyang Huanwu Decoction is a classic prescription for the treatment of qi deficiency and blood stasis,which is widely used in patients with hemorrhagic stroke.This study explores the effects of Buyang Huanwu Decoction on NIHSS score,TCM symptom score,intracranial hematoma volume,cerebral edema volume and intracranial pressure of patients with basal ganglia cerebral hemorrhage,providing clinical research support for the application of Buyang Huanwu Decoction in hemorrhagic stroke,and also providing new therapeutic ideas for the traditional Chinese medicine treatment of basal ganglia cerebral hemorrhage.MethodThe 306 selected cases were all from the neurosurgical ward of Zhongshan Hospital of Traditional Chinese Medicine,and were diagnosed as basal ganglia cerebral hemorrhage,which met the inclusion criteria.306 patients were equally divided into treatment group and control group by random number table.The control group was treated with western medicine combined with placebo.The treatment group adopted western medicine comprehensive therapy combined with Buyang Huanwu Decoction.The total course of treatment was 2 weeks,and patients’NIHSS score and TCM syndrome score were evaluated before and after treatment respectively.The changes of intracranial hematoma volume,cerebral edema volume and intracranial pressure level were evaluated before treatment,1 week after treatment and 2 weeks after treatment respectively.The clinical effeet of Buyang Huanwu Decoction on patients with basal ganglia cerebral hemorrhage was evaluated by comparing the changes of data before and after treatment.ResultsCompared with the control group,there was no significant difference in NIHSS score before treatment in the treatment group(P>0.05).Compared with before treatment,the NIHSS scores of the patients in the treatment group and the control group were significantly decreased after treatment(P<0.01).Compared with the control group,the NIHSS score of the patients in the treatment group was significantly decreased after treatment(p<0.01),and the difference of NIHSS score before and after treatment in the treatment group was significantly increased(p<0.01).The total effective rate of NIHSS score was 97%in the treatment group and 86%in the control group.The total effective rate in the treatment group was significantly higher than that of the control group(P<0.01).Compared with the control group,there was no significant difference in TCM syndrome score before treatment in the treatment group(P>0.05).Compared with before treatment,the TCM syndrome score in both the treatment group and the control group decreased significantly after treatment(P<0.01).Compared with the control group,the TCM syndrome score in the treatment group was significantly reduced(P<0.01),and the difference of TCM syndrome score before and after treatment in the treatment group was significantly increased(P<0.01).The total effective rate of NIHSS symptom score was 97%in the treatment group and 86%in the control group.The total effective rate in the treatment group was significantly higher than that of the control group(P<0.01).Compared with the control group,there was no significant difference of intra.cranial hematoma volume before treatment in the treatment group(P>0.05).Compared with before treatment,the intracranial hematoma volume in both the treatment group and the control group decreased significantly after 1 week and 2 weeks of treatment(P<0.01);compared with 1 week after treatment,the intracranial hematoma volume in the treatment group and the control group decreased significantly after 2 weeks of treatment(P<0.01).Compared with the control group,the intracranial hematoma volume in the treatment group decreased significantly after 1 week and 2 weeks of treatment(P<0.01).The total effective rate of intracranial hematoma volume was 99%in the treatment group and 95%in the control group,with no significant difference(P>0.05).Compared with the control group,there was no significant difference of the cerebral edema volume before treatment in the treatment group(P>0.05).Compared with before treatment,the cerebral edema volume in both the treatment group and the control group increased significantly after 1 week of treatment(P<0.01),the cerebral edema volume in the treatment group decreased significantly after two weeks of treatment(P<0.01),while the cerebral edema volume of the patients in the control group increased significantly after two weeks of treatment(P<0.01).Compared with 1 week after treatment,the cerebral edema volume of the patients in the treatment group and the control group decreased significantly after 2 weeks of treatment(p<0.01).Compared with the control group,the cerebral edema volume in the treatment group decreased significantly after 1 week and 2 weeks of treatment(p<0.01).The total effective rate of cerebral edema volume in the treatment group was 25%and that in the control group was 2%.the clinical effect of the treatment group was better than that of the control group(p<0.01).Compared with the control group,there was no significant difference in intracranial pressure before treatment in the treatment group(P>0.05).Compared with before treatment,intracranial pressure of patients in both the treatment group and the control group decreased significantly after 1 week of treatment(p<0.01),while intracranial pressure of patients in both the treatment group and the control group decreased significantly after 2 weeks of treatment(p<0.01).Compared with 1 week after treatment,intracranial pressure of patients in the treatment group and the control group decreased significantly after 2 weeks of treatment(p<0.01).Compared with the control group,the intracranial pressure of the patients in the treatment group decreased significantly after 1 week of treatment(p<0.05),and the intracranial pressure of the patients in the treatment group decreased significantly after 2 weeks of treatment(p<0.01).Compared with the control group,there was no significant difference in the hierarchical distribution of intracranial pressure before treatment in the treatment group(p>0.05),but there was significant difforence in the hierarchical distribution of intracranial pressure after 1 week and 2 weeks of treatment in the treatment group(P<0.01).There was no significant difference in distribution of abnormal indexes between the treatment group and the control group before treatment,1 week after treatment and 2 weeks after treatment.ConclusionBuyang Huanwu Decoction can promote the absorption of intracranial hematoma and cerebral edema in patients with basal ganglia cerebral hemorrhage,reduce intracranial pressure,and improve the neurological function and TCM symptoms of patients.Buyang Huanwu Decoction is safe and effective in the treatment of basal ganglia cerebral hemorrhage. |
PDF Full Text Request