Evaluation Of Safety And Effectiveness Of Ultrasound-Guided Percutaneous Microwave Ablation Of Subcapsular Hepatocellular Harcinoma

PurposeTo evaluate the safety and efficacy of ultrasound-guided percu taneous microwave ablation of subcapsular hepatocellular carcino ma(HCC)and to analyze the risk factors for recurrence of liver ca ncer after microwave ablation.Materials and MethodsA retrospective analysis of 53 patients with primary hepatocellular carcinoma who underwent percutaneous ultrasound guided microwave ablation(MWA)in our hospital between June 2015 and December 2017.According to the location of the lesion,all patients were divided into non-subcapsular group and subcapsular group,and the ablation results of the two groups of patients were compared.Assess complications,overall survival(OS)and local tumor progression(LTP).The Kaplan-Meier method was used to calculate the overall survival rate and local progression rate of the two groups of patients.Chi-square analysis was used to analyze the recurrence of all patients after distant ablation(P<0.05 was considered statistically significant).ResultsThe complete ablation rate of all patients after MWA was 94.3%(50\53),and there were no serious complications during ablation.The median follow-up time was 35 months.The 1-and 3-year OS rates of the two groups of patients were 95.2%,81.5%(nonsubcapsular group)and 96.8%,87.5%(subcapsular group)respectively,and the cumulative LTP rate over three yeas was 14.3%(non-subcapsular group)and 18.8%(subcapsular group).There was no significant difference in OS and LTP between the two groups(χ2 were 0.436 and 0.358;P was 0.509 and 0.549,respectively).During the follow-up period,12 patients died,and there were no lost cases.There were 17 recurrences in 53 patients.Tumor recurrence was related to the number and size of tumors and there is a risk factor for recurrence.ConclusionUltrasound-guided percutaneous MWA of subcapsular HCC is feasible.There is no significant difference in OS and LTP between the two groups,and there are no serious complications after ablation.MWA of subcapsular HCC is safe and effective.The number and size of tumors are risk factors for recurrence after ablation.