| Objectives:This study explored the relationship between spleen yin and chronic atrophic gastritis from the theory of spleen yin,and clarified the important role of nourishing spleen yin method in the treatment of chronic atrophic gastritis.Through the analysis of the nourishing spleen yin prescription,explore the indications of the medication and the rules of the prescription.Randomized,single-blind,parallel-controlled experimental methods were used to observe the effects of Shenling Baizhu San on syndromes of patients with chronic atrophic gastritis of spleen-yin deficiency type,and the changes of gastroscope scores before and after treatment.The clinical curative effect of atrophic gastritis provides reference for the traditional Chinese medicine prescriptions for enriching chronic atrophic gastritis and the clinical rational application of Shenling Baizhu San.Methods:1.This study collected the clinical research literature on the theory of spleen and yin published by the Dictionary of Formulas,China Journal Full-text Database(CNKI),Weipu Information,China Biomedical Literature Database(CBM)and Wanfang Data Knowledge Platform,and selected IBM SPSS Modeler18.0 software frequency statistics and association rules analysis and mining of the distribution characteristics of nourishing spleen yin prescription and the compatibility between drugs.2.This study collected the data of spleen-yin deficiency type atrophic gastritis admitted to the Department of Digestive Endoscopy from 2017-11-01 to 2018-11-30,and extracted 30 cases that met the criteria of this study.The patients were divided into the experimental group(Shenling Baizhu San group)and the control group(weifuchun group)by randomized,single-blind method.Each group of 15 patients underwent parallel controlled trials.The patients in the experimental group were given oral Shenling Baizhu Decoction.Oral administration,oral administration of Weifuchun tablets,taking 1 course of treatment in one month,and taking 3 courses in succession.At the end of the treatment period,the changes of TCM syndrome scores and the changes of the gastroscope scores before and after treatment were compared to observe and evaluate the clinical efficacy of Shenling Baizhu San.Results:1.Through literature search,a total of 47 prescriptions for the treatment of spleen yin deficiency were screened out.An analysis of 47 parties found that the highest frequency of single-flavored drugs was yam.According to the classification of drugs with higher frequency of use,the order of frequency from high to low is: qi medicine,blood medicine,yin medicine,water permeable medicine,phlegm medicine,and heat medicine.For the drug pairing combination,the higher frequency of use was yam and ginseng,and the higher correlation was yam and schisandra.2.The TCM syndromes in the experimental group were clinically cured in 2 cases,markedly effective in 5 cases,effective in 7 cases,and ineffective in 1 case.The total effective rate was 93.33%;the control group was cured in 1 case,markedly effective in 2 cases,effective in 10 cases,and ineffective in 2 cases.The effective rate is 86.67%.There was significant difference in the efficacy of TCM syndrome between the experimental group and the control group(P<0.05).After treatment,the TCM syndrome scores of the two groups were lower than before.The difference between the two groups was statistically significant.(P<0.05);the scores of gastroscopy in both groups were significantly lower than before,and the difference was statistically significant(P<0.05).The experimental group was significantly better than the control group(P<0.05),indicating the effect of the experimental group is better than the control group.Conclusion: Shenling Baizhu San can significantly improve the TCM syndromes and clinical symptoms of patients with chronic atrophic gastritis of spleen yin deficiency,improve gastric mucosal tissue lesions,and no obvious adverse reactions and adverse events during treatment.This suggests that the prescription is safe and effective in treating patients with chronic atrophic gastritis of spleen yin deficiency. |
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