Quantitative Study Of The Influence Of Swimming Therapy On Osteoporosis Rats Models Based On Synchrotron Radiation CT

Due to population aging,osteoporosis(OP)has become a great threat to people,especially for the elderly women.Swimming therapy,which is simple,easy,safe and effective,has been widely used in intervention and treatment of osteoporosis.Investigating the optimal load intensity in swimming therapy of osteoporosis,can provide evidence for early prevention and medical treatment of postmenopausal osteoporosis by swimming exercise.In our study,different load intensities of swimming exercises were studied on ovariectomized rats.L4 lumbar vertebrae of all the rats were dissected and scanned by Synchrotron Radiation CT(SRCT)after training.Histomorphometry analysis and Finite Element Analysis(FEA)were carried out on trabecular structure of L4 lumbar based on acquired SRCT slices,and histomorphometrical parameters and biomechanical properties were achieved.Combined with histomorphometrical parameters and biomechanical properties,the influence of different load intensities in swimming therapy on osteoporosis rats models were studied quantitatively.Our experimental results suggested that swimming exercise has a positive effect on bone mass and mechanical properties of lumbar vertebra in ovariectomized rats,indicated by greater BV/TV,BS/TV,Tb.N,compression stiffness,bending stiffness and torsional stiffness and smaller Tb.Sp in exercised groups as compared with the control group.The extent of positive intervention effect on bone in different load intensities varied from each other and moderate load intensity swimming exercise achieved the most significant effect.The optimal load intensity in swimming therapy of osteoporosis was investigated,which can provide evidence for early prevention and medical treatment of postmenopausal osteoporosis by swimming exercise.