Analysis Of Febrile Seizures And Iron Deficiency In Children And Related Indicators

Purpose In recent years,there have been more and more researches on the occurrence of febrile seizures,and more and more understandings have been made in it,such as inflammatory reactions,genetics,ion channels and other fields,iron deficiency and heat.The impact of sexual convulsions has also received increasing attention.At present,many scholars have not yet clearly and uniformly concluded the relationship between iron deficiency and febrile seizures.Some scholars believe that iron deficiency has nothing to do with febrile seizures;some scholars believe that iron deficiency increases the threshold of neuronal excitation and thus protects To reduce the occurrence of febrile seizures;it is also believed that iron deficiency can cause abnormal behavior and growth in children,mental retardation,changes in thermoregulation,impaired physical function and immune dysfunction,and also increase the risk of febrile seizures,thus suggesting iron deficiency It is one of the strengthening factors of febrile seizures.In general,iron ions play an important role in the development of the nervous system and the synthesis and metabolism of some enzymes.Iron deficiency also affects children’s cognition,growth and development,but whether iron deficiency affects the occurrence of febrile seizures.Can not be single,so we have the opportunity to further argument.This study was designed to compare the iron deficiency and iron deficiency in patients with febrile seizures and those without convulsions,and to further clarify the relationship between iron deficiency and febrile seizures and to guide febrile seizures from 3 months to 6 years old.The treatment of iron deficiency in children further makes a clinical reference for the prevention of the occurrence of febrile seizures,in order to better symptomatic and therapeutic treatment,to prevent seizures and reduce brain damage.Research objects and methods1.Subjects:3 months to 6 years old children with febrile seizures who were hospitalized in the First Affiliated Hospital of Dalian Medical University from December 2016 to December 2018,and other infectious factors of the same period and age,but no There were 180 hospitalized patients with seizures.Control group: 120 normal children with no febrile seizures were randomly selected at the same time;Experimental group: 60 patients with febrile seizures.2.Inclusion criteria The diagnostic criteria for febrile seizures are strictly based on diagnostic criteria.3.Exclusion criteria1)no history of febrile epilepsy,history of central nervous system;2)systemic infection,chronic disease and neurological deficit or developmental delay;3)Shigella gastroenteritis(based on the presence of leukemia)history of fecal cells or bloody diarrhea;4)And when parents are not working well together.5)There is a phenomenon of iron supplementation in the near January.6)The CRP value is abnormal.4.Research methods4.1 Material collection1)age,sex,time of onset,length of hospital stay,and treatment outcome;2)maternal pregnancy,perinatal conditions,whether it is premature,low birth weight,non-breastfeeding,living conditions Poor,malnourished,whether it is vaccinated according to national plans,receiving immunosuppressive agents for underlying diseases,whether it is metabolic genetic diseases,immune function development defects,nephrotic syndrome and congenital heart disease,brain dysplasia and spinal muscular muscles High risk factors such as atrophy;previous parents and relatives have a history of febrile seizures;2)blood routine,biochemical liver and kidney function,electrolytes,serum tetrairon and other results;other pathological data such as: routine,urine,blood culture;Radiological data such as brain MRI,EEG,X-ray or chest CT.3)All of the above patients obtained family consent and signed informed consent.4.2 General Analysis Procedures1)Analysis of general observation data: 1 the proportion of simple FS and complex FS;2 the distribution of gender in the control group,simple FS,complex FS;3 children with febrile seizures in different age groups;4 Iron deficiency is distributed in different age groups.2)The results of comparison between the experimental group(simple FS,complex FS)and the serum of the control group,four iron,HB,HCT,MCH,MCV,MCHC.1 Comparison between simple thermal convulsions and complex thermal convulsions in the experimental group.2 Comparison between control group and simple type FS.3 Comparison between control group and complex FS.3)Distribution of iron deficiency in the control group,simple type FS,complex type FS.4.3 Statistical methods: SPSS23.0 software was used for statistical analysis of all data.P<0.05 indicated significant difference and statistical significance.4.3 Statistical methods All data were statistically analyzed using SPSS 23.0 software,P < 0.05 indicates statistical significance.Result1.(1)There were 60 cases in the experimental group and 49 cases(81.7%)with simple febrile seizures,including 13 female children,accounting for category ratio(26.5%)and36 male children,accounting for 73.5%.11 cases of complex febrile seizures(18.3%),including 8 female children,accounting for category ratio(72.7%),3 males,accounting for category ratio(27.3%);120 controls,male children 57 People(47.5%)and 63women(52.5%).(2)There was a significant difference in the composition ratio between the simple FS and the complex FS in the experimental group.(3)The minimum age is 10 months,the maximum age is 6 years old;4 cases(6.7%)less than December,13 cases(21.7%)from December to April,and 17 cases(26.6%)from December to June,36 months-There were 13 cases(21.7%)in April,7 cases(13.3%)in 48-60 months,and 6 cases(10%)in 60-72 months.(4)The experimental components were <3 years old,3 years old-6 years old,through pearson chi square,P=0.024<0.05,iron deficiency was significantly different in age distribution.2.Serum tetra-iron,RBC,HB,MCV,MVH,MCHC were compared between the control group and the experimental group.(1)Simple type FS and complex type FS: There was no significant difference in RBC,HCT,MCV,TS,TIBC,UIBC,SI between the two samples;there was significant difference between MCH,MCHC and HB between the two samples;(2)Simple type FS and control group: There was no significant difference in RBC,MCHC,TIBC,UIBC,TS,SI between the two samples.There was a significant difference in MCV,MCH,MCHC,HB,and HCT between the two samples.(3)Complex FS and control group: There was no significant difference in RBC,TS,SI,TIBC,and UIBC between the two samples.There was a significant difference in MCV,MCH,MCHC,HB,and HCT between the two samples.3.Compared with the control group,simple FS,complex FS,the iron deficiency of the three groups was P=0.00<0.05,and the iron deficiency was significantly different between the different control groups and the experimental group.Conclusion1.Male gender is one of the strengthening factors for the occurrence of febrile seizures.The incidence of febrile seizures under 2.4 years old is high.The incidence of febrile seizures and the age of iron deficiency in children in small age groups overlap with age.Febrile seizures are associated with iron deficiency.3.The significant differences in HB,MCV,MCHC and MCH,which are more sensitive to iron deficiency among the three groups,are more obvious.4.Iron deficiency is one of the strengthening factors for the occurrence of febrile seizures.