| ObjectiveTo study the effects and mechanisms of noise on occupational groups’ neurobehavioral functions,provide evidence for preventing workers from noise and protecting their health.MethodsIn a certain chemical factory of Luzhou,100 packing workers in packing workshop were chosen as high-noise exposed group,100 technical workers in synthetic workshop were chosen as low-noise exposed group,and 100 logistical personnel in the hotels who got health examination in a certain center for disease control and prevention and had no occupational noise exposed history were chosen as control group via method of external control.The records of working environment noise levels and basic information of high and low level groups were provided by the factory,and working environment noise levels of the control group was detected before we selected objects.The Neurobehavioral Core Test Battery(NCTB)WHO recommended was used to test all subjects’ neurobehavioral functions,and workers’ catecholamine in plasma was detected through radioimmunoassay method,then analysis the correlation between neurobehavioral functions and the level of catecholamine in plasma.Results1.Comparison of workers’ basic informationAmong high-noise exposed group,low-noise exposed group and control group,the age,working years and education level of workers were found significantly different(P<0.001),and the constituent ratio of gender and nationality were found no significant difference(P>0.05).2.Neurobehavioral function test results(1)Mood state test resultsAmong the three groups,scores of negative mood state including tension-anxiety,depression-dejection,anger-hostility,fatigue-inertia were found significantly different(P<0.05),the above scores in the low-noise exposed group were all significantly higher than those in control group,and the scores in the high-noise exposed group were significantly higher than those in the low-noise exposed group(P<0.05),but scores of confusion-bewilderment were found no significant difference(P>0.05).However,scores of positive mood state vigour-activity were also found significantly different among the three groups(P<0.001),the scores in low-noise exposed group and control group were both significantly higher than those in high-noise exposed group,and scores in control group were significantly higher than those in the low-noise exposed group(P<0.05).(2)Other neurobehavioral function test resultsAmong three groups,scores of Digit Span,Digit Symbol and Pursuit Aiming were all found significantly different(P<0.05),scores of Digit Span,Results Digit Symbol and correct tapping number in the control group were all significantly higher than those in the high and low noise exposed groups,and scores in low-noise exposed group were significantly higher than those in the high-noise exposed groups(P<0.05),wrong tapping numbers in the control group were significantly less than those in the high and low noise exposed groups,wrong tapping numbers in low-noise exposed groups were significantly higher than those in the high-noise exposed group(P<0.05).Total tapping number in the control group were significantly higher than the high-noise exposed group(P<0.05),but the number were found no significant difference between the control group and low-noise exposed group or low-noise exposed group and high-noise exposed group(P>0.05).Moreover,scores of Benton Visual Retention,Santa Ana Dexterity-preferred hand and Santa Ana Dexterity-nonpreferred hand were found no significant difference among three groups(P>0.05).3.The levels of catecholamine in plasma comparison results of three groupsThe levels of adrenalin,noradrenaline and dopamine in plasma were all found significant difference among three groups,respectively(P<0.05),the adrenalin level in plasma of control group was significantly higher than that of the low and high noise exposed groups,adrenalin level of low-noise exposed group was significantly higher than that of high-noise exposed group(P<0.05).The levels of noradrenaline and dopamine of control group were significantly lower than those of the low and high noise exposed groups,noradrenaline and dopamine levels of low-noise exposed group were significantly lower than those of high-noise exposed group(P<0.05).4.Canonical correlation analysis results of catecholamine levels in plasma and neurobehavioral function test scores(1)Canonical correlation analysis results of catecholamine levels in plasma and mood stateCanonical correlation coefficient of catecholamine levels in plasma and mood state was 0.422(P<0.001).Adrenalin level in plasma was negatively related to negative mood state including tension-anxiety,depression-dejection,anger-hostility,fatigue-inertia but positively related to positive mood state vigour-activity through canonical variate.Noradrenaline and dopamine levels in plasma were positively related to the above mentioned negative mood state but negatively related to vigour-activity,and the effects of noradrenaline on mood state were greater than other two catecholamine through canonical variate.(2)Canonical correlation analysis results of catecholamine levels in plasma and short-term auditory memoryCanonical correlation coefficient of was catecholamine levels in plasma and short-term auditory memory was 0.366(P<0.001).Adrenalin level in plasma was positively related to short-term auditory memory through canonical variate.Noradrenaline and dopamine levels in plasma were negatively related to short-term auditory memory through canonical variate.(3)Canonical correlation analysis results of catecholamine levels in plasma and manual dexterityCanonical correlation coefficient of was catecholamine levels in plasma and manual dexterity was 0.377(P<0.001).Adrenalin level in plasma was positively related to manual dexterity including preferred and non-preferred hand through canonical variate,noradrenaline and dopamine levels in plasma were negatively related to manual dexterity through canonical variate.(4)Canonical correlation analysis results of catecholamine levels in plasma and perception-movement speedCanonical correlation coefficient of catecholamine levels in plasma and cognition-motor speed was 0.336(P<0.001).Adrenalin level in plasma was positively related to perception-movement speed through canonical variate,noradrenaline and dopamine levels in plasma were negatively related to perception-movement speed through canonical variate.(5)Canonical correlation analysis results of catecholamine levels in plasma and short-term visual memory abilityCanonical correlation coefficient of catecholamine levels in plasma and short-term visual memory ability was 0.186(P=0.015).Adrenalin level in plasma was positively related to short-term visual memory ability through canonical variate,noradrenaline and dopamine levels in plasma were negatively related to short-term visual memory ability through canonical variate.(6)Canonical correlation analysis results of catecholamine levels in plasma and psychomotor stabilityCanonical correlation coefficient of catecholamine levels in plasma and psychomotor stability was 0.348(P<0.001).Adrenalin level in plasma was positively related to correct and total tapping number but negatively related to wrong tapping number through canonical variate,noradrenaline and dopamine levels in plasma were negatively related to correct and total tapping number but positively related to wrong tapping number through canonical variate.Conclusion:1.Noise exposure could lead to change of workers’ neurobehavioral functions including mood state,short-term auditory memory ability,perception-movement and psychomotor stability,different noise levels have different effects on the exposed worker,changes of neurobehavioral functions in high-noise exposed group were more obvious than those in low-noise exposed group,and changes in low-noise exposed group were also more obvious than those in the control group.2.The effects of noise on neurobehavioral functions may be related to increase of noradrenaline and dopamine levels in plasma and decrease of adrenalin level in plasma of workers after they exposed noise. |
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