Study On Relationship Between Wind-dampness Syndrome With Activity Indexs Of Clinic And Patholoy In Lupus Nephritis Patients

Objective Through study the correlation between lupus nephritis(LN)Wind-dampness syndrome and renal pathology,SLE disease activity index(SLE-DAI)score,serum interleukin 6(IL 6)and complement 1q(C1q)level,explore the relationship between Wind-dampness syndrome and LN activity index,clarify the connection between LN Wind-dampness syndrome and immune-mediated inflammation,in order to provide micro and objective foundation for Wind-dampness syndrome identification,which can guide clinical syndrome differentiation and treatment.Methods 150 LN patients were selected with internalize standard,collect clinical data and serum specimens,according to syndrome differentiation of Traditional Chinese Medcine and Wind-dampness syndrome classified into two groups,Wind-dampness syndrome group 106 cases and non Wind-dampnes syndromes group 44 cases.Among these patients,119 cases have synchronous renal biopsy,who were divided into Wind-dampness syndrome group 90 cases and 44 cases of non Wind-dampnes syndrome group.Employ ELISA method to detect 88 patients(Both Wind-dampnes syndrome group-and non Wind-dampnes syndrome group are 44 cases)IL-6 and Clq expression level.Analysis the correlation of Wind-dampnes syndrome and each indicators.Results(1)Wind-dampness syndrome group of SLE-DAI scores in installment is given priority to severe activity,a total of 51 cases(48.1%).The non Wind-dampness syndrome group of SLE-DAI scores in installment is given priority to inactivity,a total of 16 cases(36.3%).Wind-dampnes syndrome group and non Wind-dampnes syndrome group have statistically significant differences in none,mild,moderate and severe activity(P<0.05).Wind-dampness syndrome group SLE-DAI score average(16.3±4.2),significantly higher than the SLE-DAI score of Wind-dampness syndrome group(8.3±2.5),the difference is statistically significant(P<0.05).(2)Wind-dampness syndrome group is obviously has more cases than that of non wind-dampness syndrome group in renal pathological type of ⅣLN(54.55%vs 6.90%),and renal pathological acute index(AI)of wind-dampness syndrome group is higher than non Wind-dampness syndrome group(P<0.05),especially in the glomerular cell proliferation,leucocyte infiltration,interstitial inflammatory cell infiltration,cells/cell fibrous crescent,platinumloop structure/micro thrombus,and other active pathological expression.However,the two groups have no difference in glomerular sclerosis,renal tubular atrophy,interstitial fibrosis and chronic index(CI).Ⅳ LN patients have higher wind-dampness syndrome integral than Ⅲ,Ⅴ,Ⅲ+Ⅴ type(P<0.05),the AI was positively related with wind-dampness syndrome integral trend(r=0.486,P=0.000<0.05),but CI has no linear correlationand with wind-dampness syndrome integral(r=0.086,P=0.086)(3)IL-6 levels of wind-dampness syndrome group was obviously higher than non Wind-dampness syndrome group,however,the Clq level of wind-dampness syndrome group is lower than non Wind-dampness syndrome group,both difference all have statistically significant(P<0.05).IL-6 levels and Wind-dampness syndrome integral have linear trend relationship(r=0.515,P=0.515),but C1q and wind-dampness syndrome integral have no linear correlation(r=0.145,P=0.145).Conclusions Wind-dampness syndrome is an important pathogenesis of LN,the wind-dampness syndrome group has a more severe acute kidney pathological damage,which is closely related to the clinical and pathological active indicators.Active LN on the syndrome of traditional Chinese medicine can be treated as"wind-dampness interference the kidney",reveals the essence of wind-dampness syndrome and recognize the material foundation for the immune-mediated renal acute inflammatory lesions.