IDEAL-IQ Sequence Quantitatively Analyze The Fat Content Of Nafld And Research The Serum Indexes Of Nafld

ObjectiveIn this study,we scanned the patients with nonalcoholic fatty liver disease,using Quantitative MRI techniques: IDEAL-IQ sequences,to quantitatively measure and analyze the fat content of patients with nonalcoholic fatty liver disease.Then we measured the subcutaneous fat area of the abdomen at the level of the umbilicus.Then we explored the the relevance between them and CT grading.In order to provide more intuitive diagnostic basis for noninvasive quantitative diagnosis of fatty liver in clinical work.MethodsSubjects: Selected 60 patients with nonalcoholic fatty liver disease and another 20 healthy people,in Qingdao Municipal Hospital,during December 2017～October 2018.Equipment: Using GE Discovery 750 3.0T MR scanner,8-channel phased-array body coil.All subjects were forbidden to eat and drink for 5-8 hours before scanning.All subjects were given breathing exercises.All subjects lay on their backs on a scanning bed.All subjects lay on their backs on a scanning bed,feet advanced,with both forearms raised,and the respiration-gated hose were placed on the most obvious place for abdominal breathing.Specific scanning parameters refer to research methods.Two radiologists who had more than 10 years’ working experience were independently diagnosed with CT images.And nonalcoholic fatty liver patients were graded by liver/spleen CT ratio.The classification standard of non-alcoholic fatty liver was based on the indexes used by the Chinese association of hepatology.We scanned the abdominal unconventional IDEAL-IQ sequences with 3.0t MRI(GE MR 750),and the images were processed using GE ADW4.6workstation.We draw 3 areas of interest with a size of 1.8cm squared on fat ratio phase diagram.Then we can get the fat fraction.We uniformly selected three areas of interest from the liver.The areas of interest should be selected to avoid intrahepatic bile ducts and blood vessels.Then we measured the subcutaneous fat area of the abdomen.All data were statistically analyzed with SPSS 24.0 software,and the measured data were expressed as(mean±standard deviation,`x±s).The difference of the fat fraction between different groups was analyzed by single factor variance analysis(ANOVA),and the difference between the two groups was compared with the LSD method.P<0.05 was statistically significant.Results1.All subjects completed the test.The images of 80 subjects were clear.The images all can be used for analysis.2.With the increase of liver/spleen CT ratio,the fat fraction was decreased.3.With CT as the gold standard,divided into fatty liver group and normal group,drawing ROC curve,the sensitivity of FF was0.91,and the specificity was 0.30.4.With CT as the gold standard,the fatty liver was divided into mild,moderate and severe group,and drawing IDEAL-IQ diagnosis the mild to moderate and moderate to severe ROC curve;then the sensitivity of IDEAL-IQ identified the mild to moderate was0.63,the specificity was 0.92,the sensitivity of IDEAL-IQ identified the moderate to severe was 0.43,the specificity was 0.88.5.There were statistically significant differences in IDEAL-IQ,subcutaneous fat area,cholesterol,high-density lipoprotein and low-density lipoprotein between the mild non-alcoholic fatty liver group and the normal group.There were statistically significant differences in IDEAL-IQ,subcutaneous fat size,cholesterol,and low-density lipoprotein(LDL)between moderate and mild NAFLD groups.There were statistically significant differences in IDEAL-IQ,subcutaneous fat area,cholesterol and low-density lipoprotein(LDL)between the moderate group and the severe group.There was no statistically significant difference in high-density lipoprotein(HDL).6.With liver/spleen CT ratio as the standard,IDEAL-IQ,subcutaneous fat area,cholesterol,high-density lipoprotein and low-density lipoprotein were significantly different between the non-alcoholic fatty liver group and the normal group.There was no statistically significant difference in high-density lipoprotein(HDL).Conclusions1.IDEAL-IQ technology can be used to diagnose and grade nonalcoholic fatty liver disease,to provide quantitative imaging indexes for nonalcoholic fatty liver disease.2.Compared with the control group,the serum indexes of cholesterol,triglycerides,low density lipoprotein and abdominal subcutaneous fat area were increased in the non-alcoholic fatty liver group.