Time In Range Is Associated With Carotid Plaque In Type 2 Diabetes

Objectives To investigate the factors associated with carotid plaque formation in patients with type 2 diabetes mellitus(T2DM)and to investigate the correlation between time in range(TIR)of blood glucose and carotid plaque.Methods Clinical data were collected from 65 patients with T2 DM aged >18 years who were admitted to the Department of Endocrinology and Metabolism of Hebei Provincial People’s Hospital between October 2019 and January 2020.To investigate the correlation between TIR and carotid plaque.The mean age of the study subjects was 53.35 ± 14.96 years,with 19 women and 46 men.The carotid intima-media thickness(CIMT)was measured by Doppler ultrasonography,and carotid plaque was defined as CIMT ≥ 1.5 mm,and was divided into two groups according to CIMT values: the plaque group and the plaque-free group.The TIR was assessed by the flash glucose monitoring(FGM)system,and the TIR ranged from 3.9 to 10.0 mmol/L.Binary logistic regression was used to investigate the factors influencing carotid plaque formation and its correlation with TIR.Results 1 Compared with the plaque-free group,the plaque group had lower TIR,older age,longer duration of diabetes,higher glycosylated hemoglobin A1c(HbA1c)and mean blood glucose(MBG),and longer time above range(TAR)(P<0.05).2 The overall incidence of carotid plaque was 53.84%,grouped by TIR quartiles,and the incidence of carotid plaque tended to increase significantly with decreasing TIR values(P for tend=0.016).3Hb A1 c was negatively and linearly correlated with TIR.4 Binary logistic regression found that age,Hb A1 c,MBG,TAR,and duration of diabetes mellitus were risk factors for plaque formation,whereas TIR was a protective factor for carotid plaque development regardless of the exclusion of confounding factors,with a 3.1% reduction in the risk of carotid plaque development for every 10% increase in TIR in the unadjusted model(P=0.039).Conclusions 1 TIR is a protective factor for plaque,and Age、diabetes course、HbA1c、MBG and TAR are risk factors.2 Hb A1 c was negatively and linearly associated with TIR.4 Binary logistic regression found that age,Hb A1 c,MBG,TAR,and duration of diabetes were risk factors for plaque formation,whereas TIR was a protective factor for carotid plaque development regardless of whether confounding effects were excluded,with a 3.1% reduction in the risk of carotid plaque development for every 10% increase in TIR in the unadjusted model.(P=0.039).Figure 6;Table 5;Reference 169...