Clinical Study On The Effect Of Home-based Pulmonary Rehabilitation For Chronic Obstructive Pulmonary Disease

Objective In this study,the patients with chronic obstructive pulmonary disease（COPD）were taken as participants,and the intervention measures of rehabilitation education（COPD management）and rehabilitation training（respiratory muscle exercise and limb muscle endurance exercise）were adopted to observe the effects of home-based pulmonary rehabilitation intervention on symptoms,lung function,exercise endurance,quality of life and acute aggravation of patients.Methods All the patients were divided into two groups,one is control group（26 cases）and another is observation group（24 cases）randomly.Patients in the control group were asked to continue to receive regular inhalation of drugs:Sinceritone covered 160ug/4.5ug budesonide formoterol（1 inhalation/twice a day）;Patients were followed up by asking the following item:medication and improvement of cough,expectoration,dyspnea,and sleep by telephone every 2 weeks.Observation group:Home-based pulmonary rehabilitation,rehabilitation education（COPD disease management）rehabilitation training（respiratory muscle exercise and limbs muscle endurance exercise）.Observation measures:We observed the following items at the start of the research and 12 weeks after the study:pulmonary function,6 min walking experiments,CAT assessment scale,m MRC dyspnea scale,EXACT-PRO acute exacerbation recognition scale,daily life activity ability scale（ADL）and leukocyte count,hypersensitive C reactive protein（hs-CRP）neutrophil lymphocyte ratio（NLR）.Statistical method:paired t test was used in group comparison.An independent sample t test,P<0.05 was statistically significant.RESULTS 1.The baseline data including gender,age,BMI,course of disease,times of acute exacerbation and complications of the two groups were comparable before the research,with no statistical significance（P>0.05）.2.After 12 weeks of observation,CAT score,m MRC score and EXACT-PRO score in observation group were lower than start of the research,and the difference was statistically significant（p<0.05）.Compared with the control group,the difference was statistically significant（P<0.05）.The walk6ming distance,ADL and 6-minute walking experiment of observation group was higher than that before observation and control group,and the difference was statistically significant（P<0.05）.Borg score in observation group was significantly lower than that in control group after walking（P<0.05）.SPO₂in observation group was higher than that in control group after walking,but there was no statistical significance（P>0.05）.3.After 12 weeks of observation,there was no significant difference in FEV₁/FVC between the observation group and the control group（P>0.05）;FEV₁in the observation group increased,but there was no significant difference（P>0.05）.5.Compared with the control group,the differences of WBC and hs-CRP in the observation group were statistically significant,but the NLR was no significant difference.Conclusion Home-based pulmonary rehabilitation therapy for COPD can effectively improve the symptoms of cough,expectoration,chest tightness and dyspnea,improve the patients’activities of daily living,improve the exercise ability,and the improvement of lung function is not significant.