Effects Of Dexmedetomidine On Cardiovascular Response And Myoclonus By Etomidate During Tracheal Intubation Induced

Objective: To investigate the effect of dexmedetomidine on cardiovascular response and myoclonus during tracheal intubation induced by etomidate.Methods: 90 ASA class Ⅰ-Ⅱ patients who underwent general anesthesia were randomly divided into three groups,control group(C group),dexmedetomidine 0.5ug/kg group(D1 group)and dexmedetomidine 0.7ug/kg group(D2 group),with 30 patients in each group.The changes of SBP、DBP、MAP、HR,myoclonus were observed in the three groups before administrating anesthetic agents(T0),before anesthesia induction(T1),before tracheal intubation(T2),immediately after tracheal intubation(T3),1 min after tracheal intubation(T4),3 min after tracheal intubation(T5),5 min after tracheal intubation(T6),10 min after tracheal intubation(T7).Results: The SBP、DBP、MAP、HR in group C at T3 and T4 were significantly higher than those at T0,and the increase amplitude were higher than those in group D1.The HR in group D2 at T1-T7 comparaed with that at T0 was lower than those in group D1.The SBP、DBP、MAP in gruop D2 at T1 、T4、T5、T6、T7 Compared with those at T0 were lower than those in group D1.There were 6 cases of mild myoclonus,7 cases of moderate myoclonus in group C,there was 1 case of mild myoclonus in group D1,there were 2 cases of mild myoclonus in group D2.Conclusion: the advance intravenous infusion of DEX is beneficial to alleviate the cardiovascular response during etomidate-induced tracheal intubation and reduce the risk of myoclonus,and D1 group was better than D2 group in hemodynamic stability.