| Objective: To evaluate the effects of neutrophil lymphocyte ratio(NLR),platelet lymphocyte ratio(PLR)and Systemic immune-inflammation index(SⅡ)on survival outcomes in renal cell carcinoma(RCC).Method: The study retrospectively analyzed the clinical data and follow-up data of 202 patients with RCC who had received surgical treatment and were confirmed in the First Affiliated Hospital of Chongqing Medical University from January 2013 to December 2017.The optimal cut-off value was obtained by X-tile 3.6.1 software.Patients were divided into two groups according to the cut point values.Univariate analysis and multivariate COX-regression model were used to analyze the relationship between inflammatory indicators and clinical characteristics and prognosis of patients.Results: The optimal cut-off values of NLR,PLR,SⅡ were 3.6,206.0,804.8 respectively.High NLR,high PLR and high SⅡ were associated with higher tumor stage(TNM stage)and worse pathological outcomes(Fuhrman grade)(P<0.05).On univariate analysis,TNM stage,Fuhrman grade,NLR,PLR and SⅡ were all significant predictors for both OS and PFS(P<0.05),and pathological type(clear cell carcinoma or not)was a significant predictor for PFS only(P<0.05).However,among NLR,PLR and SⅡ,only SⅡ remained an independent prognostic marker for both OS and PFS on multivariate analysis(HR=4.54,95% CI: 1.13～18.27,P=0.033;HR=3.27,95% CI: 1.12～9.58,P=0.031).Fuhrman grade and TNM stage were also independent prognostic factors for both OS and PFS(P<0.05).Conclusion: High preoperative SⅡ level is an independent risk factor for poor prognosis in RCC patients,and the prognostic value of SⅡ may be superior to other inflammatory markers. |
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