Effects Of Different Anesthesia Technique On Perioperative Immune Function And Quality Of Emergence In Patients Undergoing Radical Resection Of Colorectal Cancer

Objective:To investigate the effects of four different anesthesia techniques on immunity and quality of emergence among patients undergoing laparoscopic radical resection of colorectal cancer.Methods:One hundred and twenty patients with colorectal cancer receiving laparoscopic radical resection were randomly separated and getting into four groups,each group concluded thirty patients:total intravenous anesthesia（N Group）,transversus abdominis plane block（TAPB）combined with intravenous anesthesia（T group）,epidural block combined with intravenous anesthesia（S group）and TAPB combined with dexmedetomidine assisted intravenous anesthesia（TD group）.The dosage of propofol and remifentanil and the usage of vasoactive drugs were recorded after surgery.Venous blood samples were collected on the day before surgery（T₀）,1 day（T₁）,3 days（T₂）and 5days（T₃）after operation,and then tested the concentration of NK cells and T lymphocyte subsets（CD3⁺,CD4⁺and CD8⁺）,after that calculated the value of CD4⁺/CD8⁺.During emergence,cough,shivering,agitation,postoperative nausea and vomiting,the highest VAS pain score,and Ramsy sedation scores at extubation were recorded.Results:In group S and TD,the dosage of propofol and remifentanil and the occurrence of nausea and vomiting during emergence were lower than group N and T（P<0.05）,while the percentage of NK cells,CD3⁺,CD4⁺,CD4⁺/CD8⁺at T₁and T₂in group S and TD were significantly increased（P<0.05）.In group TD,the usage of vasoactive drugs during intraoperative,the incidence of cough,shivering,agitation during emergence from anesthesia were significantly lower and Ramsy sedation scores at extubation and VAS pain scores after extubation were significantly higher then group S.（P<0.05）.Conclusion:Compared with group S,T and N,group TD can mantain hemodynamic stability and effectively improve perioperative immunity and quality of emergence from general anesthesia among patients who had colorectal cancer radical resection.