Effects Of Dexmedetomidine On Perioperative Coagulation Function And Inflammatory Factors In Patients With Malignant Ovarian Tumors

Objective:In this study,patients with malignant ovarian tumor cytoreduction surgery were selected as the research object to observe the effect of dexmedetomidine on the coagulation function and inflammatory factors of patients during the perioperative period under general anesthesia.Methods:Sixty patients were selected for elective cytoreductive surgery for ovarian malignant tumors,and 60 patients were randomly divided into dexmedetomidine group（group S）and control group（group C）under the digital table method,with 30 cases in each group patient.In group S,dexmedetomidine 0.5ug/kg was intravenously pumped 10 minutes before induction of anesthesia,and then the pump was maintained at a rate of 0.2-0.6ug/kg/h until 30 minutes before the end of the operation.The same volume of normol saline was pumped intravenously into patients in group C at the same time.At various time points:before the operation（T₀）,2h after administration（T₁）,3h after operation（T₂）,collect the patient’s venous blood to detect Plt count,PT,APTT,FIB,DD;at the same time,collect the patient’s venous blood with enzymes Combined immunosorbent assay（ELISA）was used to detect the levels of plasma inflammatory factors IL-6 and TNF-α.The operation time,intraoperative fluid infusion,the amount of anesthetics,and the total intraoperative blood loss of the two groups were recorded and counted.Results:Sixty patients who met the screening criteria were included in this study.There were no significant differences between the two groups in general data,operation time,intraoperative fluid infusion,and total intraoperative blood loss（p>0.05）.1.Comparison of coagulation function between the two groups of patients at different time points:Plt at T₁and T₂in group S and C were lower than those at T₀in the two groups（P<0.05）,and both T₁and T₂in group C were lower than those in group S（P<0.05）;FIB and DD at time T₁and T₂in group S and C were higher than those at time T₀of the two groups（P<0.05）,and group C at time T₁and T₂were higher than those in group S（all P<0.05）;at time T₁There was no statistically significant difference in PT and APTT between the two groups of patients than T₀（p>0.05）.PT and APTT at T₂in group S and C were shorter than T₀in the two groups（P<0.05）,and T₂in group C was shorter In the S group（P<0.05）.2.Comparison of plasma inflammatory factor levels between the two groups of patients at different time points:IL-6 and TNF-αat T₁and T₂in the two groups were all higher than at T₀（P<0.05）,and the levels of T₁and T₂in group C were higher than at T₁S group（P<0.05）.3.Intraoperative anesthetic drug consumption of the two groups of patients:the consumption of propofol and remifentanil in group C was more than that in group S,and the difference was statistically significant（P<0.05）.Conclusion:1.Application of dexmedetomidine under general anesthesia can significantly reduce the perioperative release of inflammatory mediators in patients with ovarian malignant tumor surgery,significantly improve the postoperative coagulation status of patients,reduce the probability of deep vein thrombosis,and reduce the occurrence of postoperative complications.2.The application of dexmedetomidine under general anesthesia can reduce the consumption of anesthetics during the perioperative period,and provide a reference for selecting suitable anesthetics in clinical anesthesia.