Effects Of Different Doses Of Lidocaine On QT Interval To Patients During Anesthesia Induction In Laparoscopic Hysteromyomectomy

Objective:To evaluate the effect of different doses of lidocaine on QT interval（QTc）to patients during anesthesia induction in laparoscopic hysteromyomectomy.Methods:Eighty patients with laparoscopic hysteromyomectomy were randomly divided into groups A（blank dose group）,B（low dose group）,C（middle dose group）,and D（high dose group）with 20 cases in each group.After induction of anesthesia,groups B,C,and D were intravenously infused with lidocaine 0.5 mg/kg、1mg/kg and 1.5mg/kg respectively while group A were intravenously infused with the same volume of saline.SBP,DBP,MAP,HR and ECG（QT interval）were recorded before anaesthesia induction（T₀）,2 min after Induction drug injection（T₁）,and1,3,6min after intubation(T_2-4).Results:There was no obvious fluctuation in SBP、DBP、MAP and HR after intubation in D group,and the level of QTc in each group was prolonged after anesthesia induction,but the T2 and T3 time of the group D after intubation were shorter than those of the other three groups.To some extent,the prolongation of QTc was inhibited.Conclusion:Intravenous infusion of 1.5mg/kg lidocaine to patients in laparoscopic hysteromyomectomy after induction of anesthesia can keep the stability of hemodynamics and inhibit QTc prolongation during anesthesia induction.