Analysis Of Influencing Factors Of QT Interval Prolongation In Hospitalized Patients With Chronic Kidney Disease Stage 5

Objective:To explore the clinical characteristics and influencing factors of ECG QT interval prolongation in CKD5 hospitalized patients.Methods:The clinical data of CKD5 hospitalized patients in the Department of Nephrology of the Second Hospital of Shanxi Medical University were collected from January 1,2018 to December 31,2018 retrospectively.According to the pre-established criteria,the patients were divided into QTc prolongation group and normal group according to the prolongation of ECG QTc(corrected QT interval)in stable state.The clinical characteristics of the two groups were compared and the related factors of QTc prolongation were analyzed.Logistic regression analysis was used to analyze the influencing factors of QTc prolongation in CKD5 hospitalized patients.Results:A total of 310 patients were included,178 males(57.4%),132 females(42.6%),age[53(41,62)] years old,of which 130 were in the QTc prolonged group and 180 were in the normal group.Compared with the normal group,the QTc prolonged group was older,the proportion of patients with infection and dialysis was higher,the values of albumin,HDL-c,potassium and corrected calcium were lower,the value of the binding capacity of carbon dioxide was higher.Color Doppler echocardiography showed that the left ventricular EF value was lower and the left atrial diameter was larger.There were no significant differences in sex ratio,incidence of hypertension,incidence of coronary heart disease,incidence of diabetes,levels of hemoglobin,phosphorus,magnesium,LDL-c and left ventricular diameter by color Doppler ultrasound between the two groups.The results of multivariate Logistic regression analysis showed that hypocalcemia,serum potassium≤4.0mmol/L and having entered the stage of dialysis are independent risk factors for prolonged QTc in CKD5 hospitalized patients.Conclusion:The proportion of prolonged QTc of ECG in CKD5 hospitalized patients is high.The hypocalcemia,serum potassium≤4.0mmol/L and having entered the stage of dialysis are independent risk factors for prolonged QTc in in CKD5 hospitalized patients.