Plasma Triglycerides Levels And Central Obesity Predict The Development Of Kidney Injury In Chinese Community Older Adult

Objective:The prevalence of chronic kidney injury in the elderly is increasing day by day,despite the achievement of blood glucose,blood pressure targets,the risk for kidney injury remains high among older adults.This observational retrospective study from 2011 to 2013 investigated whether dyslipidemia and central obesity-high Triglyceride(TG)or high waist circumference(WC)contribute to this high residual risk for kidney injury.Contents and Methods:A total of 843 elderly aged over 60 years old were selected in the physical examination center of Junliangcheng Hospital of Dongli District,Tianjin.Basic data and blood and urine specimens were collected for testing separately,and based on the test data,screened 666 individuals with a baseline estimated glomerular filtration rate(e GFR)≥60 m L/min/1.73m2 and negative microalbuminuria completing a 3-year follow-up.At baseline,subjects were grouped according to the levels of TG and WC,in other words,TG ≥ and <1.7 mmol/L,WC ≥ and <90 cm(male)or 85 cm(female).The primary outcome was kidney injury after 3 years of follow-up,defined as low e GFR(e GFR<60 m L/min/1.73m2)or reduced e GFR(e GFR decreased > 25%)or UACR ≥ 30 mg/g(urinary albumin to creatinine ratio,UACR).The CKD-EPI equation was used to calculate e GFR,the ratio of urinary albumin to creatinine was calculated,and the odds ratios(ORs)and 95% confidence interval(CIs)for kidney injury and risk factors(including TG and WC)were evaluated by unconditional logistic regression.Results:1.Overall,6.01% of subjects developed low e GFR,11.11% reduced e GFR,25.98% UACR≥30 mg/g and 3.45% low e GFR and UACR≥30 mg/g after 3 years of follow-up.2.Subjects with TG≥1.7mmol/Land WC≥90cm(male)or 85cm(female)had a higher incidence of kidney injury than those with normal TG or WC.3.The relationship between TG and the risk of kidney damage: adjust the related confounding factors in sequence.After adjusting gender and age in model 1,there is a high risk between TG≥1.7mmol/l and e GFR<60 m L/min/1.73m2(OR=2.44,95%CI=1.27-4.68);TG≥1.7mmol/l increased the risk of UACR≥30 mg/g by 32%,and of developing both abnormalities by 1.41-fold;further adjustment for potential confounders factors,the association is slightly weakened in model 2 and 3.4.The relationship between WC and the risk of kidney damage: adjust the related confounding factors in sequence.After adjusting gender and age in model 1,WC≥90cm(male)or 85cm(female)was associated with the risk of e GFR<60 m L/min/1.73m2(OR=2.68,95%CI=1.25-5.75),WC≥90cm(male)or 85cm(female)increased the risk of UACR≥30 mg/g by 1.43-fold,and of developing both abnormalities by 1.89-fold;further adjustment for potential confounders similarly in models 2 and 3,the association is slightly weakened.Conclusions:In a population of Chinese community-dwelling older adults,high TG and central obesity were risk factors for the development of kidney injury over 3 years.