Racial Disparities In The Survival Of Early Breast Cancer Patients Who Underwent Breast-conserving Surgery

Objective:In the current study,we aimed to provide a clear insight on the racial disparity of breast conserving rate(BCR)and survival in breast cancer after breast conserving surgery(BCS).METHODS: Using data from the Surveillance,Epidemiology,and End Results program(SEER),we estimated breast cancer incidence rates and the rate of BCS by race in two periods(2000-2004 and 2013-2017).Relative survival analysis was based on patient-level data from 1998 to 2017.To be adjusted for baseline differences for different races,inverse probability weighting(IPW)models were stepwise performed.RESULTS: From 2000-2004 to 2013-2017,both the breast cancer incidence(from4.18 to 5.05 per 1000 white women)and the proportion of patients after BCS(from55.5% to 59.9)were highest in whites than that of other races.Black individuals’ incidence(1.20 per 1000 black women or relatives 43.6% increased)and the BCR were increased most rapidly(6%)than other races.Asian or Pacific Islanders(APIs)were less likely to be diagnosed at a later stage and had the best prognosis than those of other races.After baselines fully adjusted,whites had the better Breast Cancer Specific Survival(BCSS)and Overall Survival(OS)than that of minorities(all p<0.001).CONCLUSIONS: We identified the racial disparities of breast cancer incidence,BCR,and survival differences.We found increase trends of breast cancer incidence and BCR in minorities;however,we also identified the worse survival of minorities than that of whites,regardless of age,tumor stage,grade,and Luminal subtype.