Chemical Separation And Purification Of Medical Isotope ^99mTc Produced By Accelerator

^99mTc is the most widely used diagnostic radionuclide in clinical medicine.The direct production of ^99mTc on cyclotron accelerators via the ¹⁰⁰Mo（p,2n）^99mTc reaction has been considered as the most promising approach with many advantages,such as no reactors、no highly enriched uranium、less radioactive waste and no nuclear proliferation.Hence,the present work carried out the investigation of medical isotope^99mTc produced by superconducting linear accelerator,which aim at laying foundation for our country production ^99mTc in the further.The main research is as following:1.The selecting of resins for Mo/^99mTc separation was studied from several domestic resins firstly.Static and dynamic adsorption experiments were carried out,in which the effects of alkali concentration,contact time,resin amount and the flow rate on the adsorption of Re（VII）were investigated.The resin was characterized by infrared spectroscopy and the irradiation resistance of the resin was also tested.The results showed that AM-101 resin has a high selectivity toward Re（VII）.The adsorption process of Re（VII）on AM-101 resin was conformed to the pseudo second order kinetics model.The adsorption performance of AM-101 resin to Re（VII）was not affected after irradiation.2.The production of ⁹⁹Mo/^99mTc was conducted by 18.5 Me V proton bombarding enriched molybdenum-100 target on a superconducting linear accelerator.The chemical separation of ^99mTc was achieved through the established three-column separation and purification device.The results shown that medical isotope ^99mTc produced successfully,which verifies the feasibility of present production method.The impurity elements Nb and Mo have been effectively removed by the three-column purification system,which realized effective separation of ^99mTc from a large exess of Mo.3.The studies of recovery Mo from alkaline solution was performed.Results showed that acetic acid was a good precipitant and the Mo precipitation efficiency can reach 99%.At the same time,it was found that the removal efficiency of K ion.The Mo sediment was reduced by hydrogen at high temperature and recycled metal Mo was obtained,the recovery rate of Mo was about 90%.It has significantly reduced the cost of direct production ^99mTc by accelerator.