Study On The Decorporation Performance Of Glycyrrhiza And Its Derivatives On Uranium

As one of the key nuclides in the nuclear fuel cycle,uranium has strong chemical toxicity,radiation toxicity and long half-life,posing a serious threat to public safety.Once uranium enters the body,it is characteristically deposited in the kidneys and bones,causing severe damage to organs and causing DNA and protein breaks.At present,there are existing excretion agents that can promote the excretion of uranium,but their low biocompatibility and weak ability to promote excretion in bones make their development limited.Traditional Chinese medicines are natural medicines or their processed products,which have good biocompatibility and have a certain protective effect on radiation damage.Therefore,this paper selected Glycyrrhiza,a natural traditional Chinese medicine,through preliminary research,and synthesized two Glycyrrhiza derivatives Fe₂O₃@Glycyrrhiza and Fe₃O₄@by compounding nano-iron oxides（Fe₂O₃ and Fe₃O₄）with good magnetic and biocompatibility with Glycyrrhiza.The Glycyrrhiza derivatives were analyzed by means of scanning electron microscopy（SEM）,infrared（FTIR）,X-ray diffraction（XRD）,and X-ray photoelectron spectroscopy（XPS）,and their ability of decorporation at cellular and mouse levels were investigated.Boosting effect.The specific work is as follows:（1）Simple pretreatment of Glycyrrhiza,and composite with Iron Oxide Magnetic Nanoparticles to prepare and synthesize two kinds of iron oxide-based Glycyrrhiza derivatives.The materials were characterized by various analytical methods,and the adsorption properties of the materials in the in vitro environment were explored.The maximum adsorption capacity of Glycyrrhiza for U（VI）was 252 mg/g,and the adsorption equilibrium time was 4 h;while Fe₂O₃@Glycyrrhiza and Fe₃O₄@Glycyrrhiza had faster adsorption equilibrium time,3 h and2 h,respectively,and the adsorption equilibrium time was 3 h and 2 h,respectively.（VI）has better selectivity.（2）The evaluation of toxicity and decorporation ability at the cellular level showed that Glycyrrhiza,active ingredients of Glycyrrhiza and derivatives of Glycyrrhiza all had lower cytotoxicity than CaNa₃-DTPA.The evaluation of decorporation ability found that glycyrrhizic acid and glycyrrhizinate can promote the excretion of 52.6%and 57.3%of uranium in cells,respectively,and Fe₂O₃@Glycyrrhiza and Fe₃O₄@Glycyrrhiza can also promote the excretion of 43.4%and 21.7%of uranium in cells.The ability is better than the commercially available CaNa₃-DTPA.（3）Evaluation of the effect of promoting excretion at the actual biological level in mice.It shows that both glycyrrhizinate and glycyrrhizic acid are drugs with strong decorporation ability,and glycyrrhizinate is more suitable for emergency treatment after uranium pollution.Immediate administration can promote 56.3%uranium in the kidneys,and in the bones.The excretion of 18.3%uranium;while glycyrrhizic acid has both an decorporation effect and a protective function.Immediate administration can promote the excretion of 53.2%uranium in the kidneys and 10.5%uranium in the bones.In the case of preventive administration,it can prevent the excretion of uranium.55.2%and 23.9%of uranium were deposited in kidney and bone,both better than commercially available CaNa₃-DTPA.