Studies On Difunctionalization Of Alkenes Catalyzed By Nitrogen Heterocyclic Carbenes

Alkenes are commonly used synthetic molecules containing carbon-carbon double bond functionality.The 1,2-difunctionalization of alkenes enables the synthesis of organic comple x molecules from simple starting materials.Therefore,the exploration and development of no vel,efficient and green olefin conversion methods is of great significance in organic syntheti c chemistry.The multi-component reaction based on free radical intermediates catalyzed by n itrogen heterocyclic carbene is a new type of catalytic method,this work shows the potential application in the realm of pharmacy and organic synthesis.This thesis is divided into the fol lowing three chapters:Chapter 1: Firstly,the development history of N-heterocyclic carbene is briefly reviewe d,and the types of N-heterocyclic carbene are introduced.Then,the research progress of N-h eterocyclic carbene catalyzed single electron transfer reaction and bifunctionalization of olefi ns is briefly introduced.Chapter 2: We designed a thiazole-based carbene catalyst to catalyze the perfluoroalkyla tion acylation of olefins,and completed the construction of α-aryl β-perfluoroalkyl ketones.T he reaction strategy is simple,efficient,and environmentally friendly,which meets the requir ements of green chemistry.It provides a reliable method for the synthesis of fluorine-containi ng α-aryl ketones.We carried out preliminary research on the reaction mechanism and propo sed a reasonable reaction mechanism.Chapter 3: We designed a kind of photoinduced and N-heterocyclic carbene catalyzed o lefin 1,2-acylation,in which Hantzsch esters readily generate acyl radicals under visible light irradiation.In this reaction,we designed a triazole carbine catalyzed olefin 1,2-diacylation method.