Synergistic Photothermal Therapy-chemotherapy With UCST-LCST Dual Thermal Response Macromolecular Modulation

Cancer is becoming more serious as people’s standard of living improves,and the survival rate of cancer patients is low due to metastasis and recurrence,necessitating the development of a method that can inhibit both tumor growth and metastasis.Nanomedicine development has become a watershed moment in cancer treatment,with many already in clinical use in chemotherapy,gene therapy,radiotherapy,immunotherapy,and photothermal therapy（PTT）.Recently,NIR laser-mediated PTT has attracted increasing attention as an emerging treatment strategy for breast cancer due to minimal invasiveness,better preservation of surrounding tissues and lower complication rates.PTT-induced thermal effects not only accelerate the cellular uptake of chemotherapeutic agents,but also enhance the cytotoxicity of chemotherapeutic agents in vitro and in vivo.Chemiluminescent thermotherapy has shown great potential to inhibit tumor growth.However,achieving maximum synergistic chemistryphotothermal efficacy is challenging due to the low efficiency of controlled chemical drug release from external or internal triggers,while photothermal therapy kills tumor cells with damage to surrounding normal tissues,which becomes a challenge to overcome its shortcomings.Therefore,a nano-delivery system that can effectively achieve photothermal therapy and dual stimulation of responsive drug release to inhibit primary tumor growth and metastasis is needed.The nanoplatform we designed is nontoxic,has a high safety profile,and can inhibit the growth and metastasis of primary tumors.