Study On Synthesis Of Polysubstituted Benzene And Quinoline Rings Based On Iodine Elemental Catalyzed Carbon Heterobond

The sulfur-containing and nitrogen heterocycle compounds are widely present in natural products and organic drug molecules and are applied to various chemical fields.With the development of organic synthetic chemistry,they are increasingly embodied,with two aryl sulfide and quinoline derivatives play an important role in such compounds.It has found that they contain them in many organisms,and at the same time,the diaryl sulfide and quinoline derivatives are also applied to the organic semiconductor materials,functional materials and bioengineering.The synthesis method of the diaryl sulfide compound and quinoline derivative has been developed and improved by organic chemists and medical research and developers in recent years.Therefore,a method of developing a simple material,no transition metal catalysis,simple and efficient synthesis of diaryl sulfide and quinoline compound is still a popular research direction in modern synthesis.This paper proposes(a)aromatic amine and thiol-based starting materials synthetic diaryl sulfide compound(b)aromatic amine and phenylacetaldehyde for raw materials,two components,synthesis 3-substituted quinoline derivatives.The main research contents are as follows:1.Under the conditions of the metal-free catalyst,the two components were reacted with a high yield by a high yield to obtain a diaryl sulfide compound in high yield.The reaction is inexpensive for the catalyst,DMSO is a promoter,and the reaction exhibits good substrate applicability and functional group stability,and different types of products can be obtained after fine-tuning the reaction conditions.The reaction raw material is simple,no pre-functionalization,the gram-level reaction can also obtain excellent yield,providing a new method for high-efficiency synthetic sulfur ether compounds.2.Under the conditions of the monohydric iodine as the catalyst,the acetic acid is an additive,3-phenylbenzene quinoline is formed by naphthyl amine and phenylacetaldehyde.The reaction has excellent chemical selectivity,and the reaction conditions are mild,and the generation of C-H/C-C,C-C/C-N bonds is achieved under non-metallic conditions,providing new ideas for synthetic quinoline derivatives.