Preparation And Drug Release Properties Of Modified Natural Polymer Hydrogels With Near Infrared Response

Traditional hydrogels have disadvantages such as poor mechanical properties,single function and limited drug delivery,which limit their application in specific fields.In recent years,natural polymer hydrogels have attracted the attention of scientists in the field of building intelligent drug delivery systems because of their excellent biocompatibility,biodegradability,good water absorption,retention performance and the design of drug load.Therefore,the development of new modified natural polymer hydrogels have become a research hotspot in this field.Compared with ultraviolet or visible light,near-infrared light has the advantages of high triggering,deep penetration of effective tissue and fewer side effects,and is often used in drug release triggers.In this study,we designed and prepared two kinds of drug-loading modified natural polymer hydrogels with drug delivery control performance,combined with nearinfrared light to achieve drug delivery control effect,and studied and analyzed their structural morphology,drug release behavior,as well as in vitro antibacterial properties.The details are as follows:1.Preparation and characterization of PVA-CCS-SF-GO-CIP potion loaded gelThe basic principle of the rapid sterilization of the near infrared response potionloaded gel is attributed to the fact that the hydrogel converts the absorbed near infrared light into heat,which rapidly heates the hydrogel,thus accelerating the release of the drug loaded in the pore.In the design of NIR potion carrying gel,one of our main ideas is to use the synergistic effect of antibiotics and NIR to realize the space-time control of antibiotic release and hyperthermia triggered by NIR,so as to achieve the synergistic antibacterial effect.In this chapter,using polyvinyl alcohol(PVA),carboxylated chitosan(CCS),silk fibroin protein(SF)and graphene oxide(GO)as raw materials,PVA-CCS-SF GO hydrogel was prepared by freeze-thaw method,and then loaded with antibacterial drugs to obtain potion carrying gel.The structure,morphology and properties of hydrogel and potion carrying gel were characterized.The results showed that the addition of GO not only significantly improved the mechanical properties and swelling properties of the hydrogel,so that the drug loading capacity of the hydrogels was better,but also could be used as a photothermal agent.In vitro drug release results showed that PVA-CCS-SF-GO-CIP potion gel showed good sustained release performance.Further near-infrared controlled release studies showed that PVA-CCSSF-GO-CIP potion gel could effectively control the release rate of drugs by turning on and off the near-infrared light.In addition,PVA-CCS-SF-GO-CIP potion gel showed good antibacterial activity in vitro.2.Preparation and characterization of Dex IEM-GM-Laponite-CIP potion loaded gelDextran(Dextran)is a natural and renewable biological macromolecule with excellent biodegradability and good biocompatibility.Dextran and its derivatives(Dex IEM)are functional polymers used to construct drug delivery systems.Synthetic saponite(Laponite)is a synthetic layered clay commonly used as a multifunctional crosslinker or nano-filler to improve the mechanical strength of the material.GO is highly susceptible to agglomeration,and vinylated GO(GM)can not only improve the dispersion of GO in solvents,but also be used as a photothermal agent.In this chapter,Dex IEM,Laponite and GM were used as raw materials.First,Dex IEM-GM-Laponite hydrogel was prepared by free radical polymerization method,and then loaded with antibacterial drugs to obtain potion-carrying gel.The structure,morphology and properties of hydrogel and potion-carrying gel were characterized.The results showed that with the increase of Laponite content,the cross-linking density of hydrogel increased,the mechanical properties improved significantly,and the drug loading effect was good.The results of in vitro drug release study showed that the lotion carrying gel showed good continuous release ability.The near-infrared controlled release test results showed that the Dex IEM-GM-Laponite-CIP potion gel could effectively control the release rate of the drug by turning on and off the near-infrared light.In addition,the lotion carrying gel also showed excellent antibacterial effect.In summary,we designed and prepared a modified natural polymer lotion carrying gel with near infrared response controlled drug release,which has excellent controlled drug release effect and good bactericidal performance,providing a new idea and basis for the application of near infrared light response materials in antibacterial therapy.