Nickel-Catalyzed Reductive Coupling Of Tertiary Alkyl Halides With Benzyl Chlorides And Chloroformates

The thesis introduces mainly Nickel-catalyzed reductive coupling of unactivated tertiary alkyl halides with benzyl chlorides and chloroformates to construct benzylated quaternary carbon centers.The method features mild reaction conditions,high functional group tolerance,wide range of substrates and no isomerization products.Preliminary mechanistic studies indicate that the reaction may involve alkyl radical mechanism.The thesis is divided into the following three parts.The first part mainly summarizes the developments of benzylation strategy and the research progress on transition metal catalyzed reactions to create quaternary carbon centers.The second part introduces Nickel-catalyzed reductive coupling of unactivated tertiary alkyl halides with benzyl chlorides and chloroformates,including condition optimization,substrate expansion and mechanism research.The third part describes the relevant experimental operations and experimental data in detail.