| With the acceleration of economic globalization,large multinational pharmaceutical companies have adjusted their industrial structure and refined their international division of labor.In this process,my country has become the most important pharmaceutical intermediate production base,and the pharmaceutical intermediate industry has also gained rapid develop.The number of enterprises producing pharmaceutical intermediates in my country is large in number and small in size,and most of them are small and micro enterprises located in vast towns and villages,resulting in serious environmental pollution problems.The wastewater pollutants produced in the production process of pharmaceutical intermediates are complex,and the wastewater quality has the characteristics of high CODcr concentration,high NH4+-N concentration,high salt content,and deep chromaticity.This kind of production wastewater is difficult to treat.In this study,the Pharmaceutical intermediate production wastewater produced in the production process of a pharmaceutical factory in Shandong was taken as the research object.An experimental study was carried out and the following conclusions were drawn:（1）When using alkali precipitation to treat high concentration pharmaceutical intermediate production wastewater,through the experimental analysis of three alkali adjustment methods,reaction time and precipitation time,the best experimental parameters are determined.The experimental results show that the best experimental conditions for alkali precipitation treatment are as follows:Adjust the pH value to about 7.0 with Cao,and then adjust the pH value to about 11.7 with 30%NaOH solution.The water inlet temperature is 40℃,the reaction time is 8 h,and the precipitation is 30 min after the reaction.Under these experimental conditions,the removal rates of CODcr and NH4+-N were 28.10%and 85.3%respectively.The effluent CODcr was about 10600～11800 mg·L-1 and the effluent NH4+-N was about 200～210 mg·L-1.（2）The response surface analysis method is used to analyze the influencing factors of NH4+-N removal rate of alkali precipitation.The results show that except that the interaction between influent temperature and reaction time is small,the interaction between other factors is obvious,the highest point of the response surface is prominent,and the NH4+-N removal rate has the best value within the selected range of factors.The response surface analysis method is used to optimize the experiment.The optimization results show that:The test conditions of influent pH value of 11.66,influent temperature of 39.57℃ and reaction time of 7.27 h are the working point with the maximum NH4+-N removal rate.At this time,the theoretical NH4+-N removal rate is 81.25%.The test conditions are corrected as follows:the influent pH value is 11.7,the influent temperature is 40℃,the reaction time is 7.3 h,the precipitation time is 30 min,the corresponding NH4+-N removal rate is 83.23%,and the effluent NH4+-N concentration is 220～240 mg·L-1.（3）The study on the factors affecting the operation of UASB reactor shows that under the conditions of influent temperature of 35℃,organic load of 4.5 kgCOD·（m3·d）-1,hydraulic retention time of 48 h,influent pH value of 7.5 and adding 200 g·m-3 anaerobic biological agent,the UASB reactor has a better treatment effect on the wastewater;At this time,the influent CODcr concentration is about 10600-11800 mg·L-1,the effluent CODcr concentration is 3800～4050 mg·L-1,and the CODcr removal rate is about 65%,but the NH4+-N concentration and TN concentration rise slightly.（4）The factors affecting the operation of SBR reactor are studied.Under the conditions of influent temperature of 25～30 ℃,pH value of 6.5～7.0,dissolved oxygen DO concentration of 4 mg·L-1,aeration time of 14 h,mixing time of 2 h,sedimentation time of 130 min,influent and drainage time of 20 min and addition of 200 g·m-3 aerobic biological agent,the SBR reactor has a good treatment effect on the wastewater.At this time,When the influent CODcr concentration is 3800～4050mg·L-1,the effluent CODcr concentration is 550～570 mg·L-1,and the CODcr removal rate is about 85%;When the influent NH4+-N concentration is 320～340 mg·L-1,the effluent NH4+-N concentration is 60～70 mg·L-1,and the NH4+-N removal rate is about 79%.（5）When quartz sand filtration is used to treat high concentration pharmaceutical intermediate production wastewater,the optimal experimental parameters are determined through experimental analysis of the influent temperature.The experimental results show that the optimal experimental conditions of quartz sand filtration are:when the influent pH value is about 7.0 under normal temperature.The CODcr concentration of influent is 550～570 mg·L-1,the CODcr concentration of effluent is 430～460 mg·L-1,and the CODcr removal rate is about 21%.（6）Activated carbon adsorption was used to treat high concentration pharmaceutical intermediate production wastewater.Through the experimental analysis of influent pH value and temperature,the best experimental parameters were determined.When the normal temperature pH value is about 7.0,the influent CODcr,NH4+-N,TN and TP concentrations are 430～460 mg·L-1,60～70 mg·L-1,70～80 mg·L-1 and 0.5～0.55 mg·L-1 respectively,and the effluent CODcr NH4+-N,TN and TP concentrations are 180～195 mg·L-1,32-38 mg·L-1,43～48 mg·L-1 and 0.3～0.32 mg·L-1 respectively,and the pH value is about 7.0.The effluent meets the discharge standard of water pollution for chemical synthetic pharmaceutical industry（GB21904-2008）. |
