Preparation Of Photoluminescence Composite Film And Its Application In Microfluidic Technology To Synthesize Dydrogesterone Intermediate

Dydrogesterone is a typical steroidal drug,which is a common oral progesterone in medical treatment,especially in the treatment of female health.However,the domestic production technology is far lower than that of foreign pharmaceutical companies,which makes domestic demand rely on imports.In the domestic mature and green feasible process,the photoisomerization synthesis of 9β,10α-dehydroprogesterone ketal is a key step.However,most of the reaction light sources are high-pressure mercury lamps.Researchers can obtain the reaction wavelength by glass filtering,which will reduce the utilization of photons.In addition,the release effect of the high-pressure mercury lamp is serious,which is not conducive to green industrial production.In this article,the idea of replacing the high-pressure mercury lamp with low-pressure mercury lamp is proposed.The low-pressure mercury lamp is used as the ring-opening and ring-closure light source to achieve excellent reaction effect and the green synthesis concept with low energy consumption.According to the requirements of the ring-opening and ring-closure reaction wavelength,based on the current band intensity of low-pressure mercury lamps,the article prepares the photoluminescent LB-PDMS composite film with good performance to obtain the feasible UVB radiation intensity by converting the incident wavelength and uses it on the synthesis of dydrogesterone intermediates based on microfluidic technology.Therefore,it is proposed to use the 8 W 254 nm mercury lamp as the ring-opening light source,and the integrated light source of the LB-PDMS composite film with sufficient UVB intensity and the 8 W 254 nm mercury lamp as the ring-closure light source.And the microfluidic technology is also used to realize the photoisomerization synthesis of 9β,10α-dehydroprogesterone ketal.In the experiment,the composite films with good luminescence and stability properties were prepared.In the photochemical microfluidic reaction,it was found that the emission intensity of UVB increases about 10 times when the flexible and movable composite film is integrated with the 8 W lamp,and it can produce up to 100 W lamp productivity without any cooling devices.We also determined the reaction effect and reaction conditions of the new craft.Under the new craft,35%yield and about 55%selectivity were obtained,showing the great potential to replace the traditional high-pressure mercury lamp.The traditional photochemical synthesis process was successfully optimized,and achieved the target of effective green synthesis of 9β,10α-dehydrogeprogesterone ketal by low-pressure mercury lamp.In addition,a calculation method based on photon flux and photon efficiency is proposed to evaluate the specific wavelength effect,which can provide theoretical guidance for the wavelength range of photochemical microfluidic processes.Finally,a simple kinetic study on the photochemical isomerization of 9β,10α-dehydroepiandrosterone ketal was carried out under the proposed new craft,which provided a theoretical basis for industrial production.