The Study Of Substitution Of Halogenated Hydrocarbons By 4-Acyl-1,4-Dihydropyridine Compounds

As an important nitrogen-containing heterocyclic amines,1,4-DHPs is widely used in the treatment of various diseases,including hypertension and heart disease because of its own biological activity.In addition,due to the effect of light or Na₂S₂O₈,etc,the fourth substituent of 1,4-DHPs can produce free radicals,therefore,1,4-DHPs is widely used in various addition and substitution reactions.Due to its good biological activity,diaryl ketones have been used in various anti-inflammatory drugs and antibiotics.In addition,due to its UV-Stability,it has been added to all kinds of paints and plastics.It can also be used as the starting material of synthetic dyes,gonadotropins and puzzle drugs.Diphenyl ketone is a kind of fixative of perfume,it also can be used as an initial raw material for manufacturing hypnotics,antihistamines and insecticides.4-acyl-1,4-DHPs can produce acyl radical under blue visible light irradiation.In this paper,the substitution reaction of free radical for iodobenzene and its analogues is studied,NiCl₂·DME is used as catalyst,Na₃PO₄ is used to provide alkaline conditions,DMSO is used as solvent,from moderate to high yields,28 different diaryl ketones were synthesized,the scope of application of this reaction is explored,the effects of steric hindrance,electron withdrawing and electron donating substituents on the reaction are studied.In addition,the effect of different halogen atoms on the reaction is explored.The reaction can be used in a wide range and carried out at room temperature,it can be carried out smoothly without using any toxic and harmful hazardous substances,which can provide a new solution for the synthesis of some diaryl ketones with thermosensitive groups.