Water-Mediated Catalytic Decarboxylation Enabled Polysubstituted Furans And Allylic Alcohols With Exclusive (E)-Configurations

In the life sciences,synthetic chemistry plays an important role in the research and development of biology.In recent years,reducing or eliminating the use or genera-tion of hazardous substances in chemical processes attracts widespread attention which is environmentally benign and of high significance to sustainable chemistry.The development of green organic synthesis reactions is the direction that synthetic chemists have been working hard on.To develop water-mediated synthetic methodologies is interesting and of great significance for sustainable chemistry for water is readily available and non-toxic thus serving as an ideal green reaction partner or media/solvent.However,to develop such a process in synthetic chemistry typically is not an easy task mainly due to two reasons:（i）water is a very weak nucleophile and generally is extremely unreactive;（ii）water is quite polar and the presence of water in the or-ganic system could result in an insoluble mixture of other organic ingredients thus stopping the reaction.The synthesis of polysubstituted furans with water as an O-donor is challenging.Therefore,it is of great research significance to explore green methods to synthesize functional furan and allyl alcohol molecules with biological activity,which also meets the development requirements of green and sustainable chemistry.Polysubstituted furans and （E）-allyl alcohols are frequently found in pharmaceu-ticals,natural products and functional materials,and also serve as intermediates in synthetic chemistry.The bioactive furan and （E）-allyl alcohols has been widely used in all walks of life and has important research significance.Therefore,we synthesized functional cyclic carbonates using carbon dioxide as an intermediate and water as a weak nucleophile by palladium-catalyzed decarboxylation of carbonates with water to construct multi-substituted functional furan and （E）-allyl alcohol.The water-mediated catalytic decarboxylation process to form polysubstituted furans and （E）-allyl alcohols.It has broad functional group tolerance and is easy to operate and only produces CO₂ by-products under mild environmental conditions.A series of control experiments revealed the key role of water for successful conversion and the origin of chemoselectivity and stereoselectivity.