Synthesis Of Cerium Oxide-based Quantum Dots And Application In Detection Of Antibiotics

In recent years,antibiotics have been frequently detected in the global water environment.With the increasing pollution of antibiotics in the water environment,the antibiotic pollution in the water environment has been proved to be harmful to the ecological environment,so effective detection of antibiotics in the water environment has become more and more important.There have been a large number of reports on the detection and analysis methods of antibiotics in the water environment,but the instruments used in the traditional detection methods are relatively expensive,the operation steps are cumbersome and are not suitable for on-site rapid detection.Therefore,it is very urgent to develop a new detection method with simple operation,rapid determination and high sensitivity.This article has established three electrochemical detection methods for the three types of antibiotics of oxytetracycline,penicillin G sodium,and sulfadiazine,and applied these methods to the actual sample detection to realize the stable and rapid determination of the above antibiotics,and explore the antibiotics The main research results of the electrochemical reaction mechanism at the electrode interface are as follows:1.Using the porous carbon of the hollyhock stem as the biological template,the Ce O₂-Co₃O₄ QDs/C composite material was successfully prepared by the hydrothermal method-biological template method and modified on the surface of the glassy carbon electrode for the detection of oxytetracycline.The electrochemical analysis method was used to analyze the catalytic oxidation behavior of oxytetracycline on the surface of Ce O₂-Co₃O₄ QDs/C@GCE.The research results show that under the best experimental conditions,Ce O₂-Co₃O₄ QDs/C@GCE also shows good electrocatalytic activity for oxytetracycline,and the peak current and the concentration of the oxytetracycline test solution show a good linear relationship in the range of 1×10^-8～1×10^-4,the standard curve equation can be expressed as y=0.3585x+3.1137（R²=0.9991）,and the detection limit is 2.33 n M（S/N=3）.In addition,good results have been obtained in the detection and analysis of actual samples.2.Using lignocellulosic thin-layer carbon as a biological template,the Ce O₂-Cu O QDs/C composite material was successfully prepared by the dipping method,and the material was modified on the surface of the glassy carbon electrode for electrochemical detection of penicillin G sodium.The electrochemical analysis method was used to study the catalytic oxidation behavior of penicillin G sodium on the surface of Ce O₂-Cu O QDs/C@GCE.The research results show that under the optimal experimental conditions,this Ce O₂-Cu O QDs/C can exhibit strong electrocatalytic activity for penicillin G sodium,and the linear response range of peak current and penicillin G sodium test solution is 1×10^-8～5×10^-4,the standard curve equation can be expressed as y=0.3088x+2.8326（R²=0.9979）,the detection limit is 1.57n M（S/N=3）,and in the anti-interference test and actual samples All showed good performance in testing.3.Using sodium caseinate as the biological template,the Ce O₂-Fe₂O₃ QDs/SC composite material was successfully prepared by the hydrothermal method-biological template method.Cyclic voltammetry（CV）,differential pulse voltammetry（DPV）and electrochemical impedance test（EIS）were used to analyze and study the electrocatalytic performance of sulfadiazine on the surface of Ce O₂-Fe₂O₃ QDs/SC@GCE.The experimental results show that under the optimal experimental conditions,Ce O₂-Fe₂O₃ QDs/SC exhibits strong electrocatalytic performance for sulfadiazine,and the linear response range of peak current and sulfadiazine test solution is 1×10^-8～1×10^-4,the standard curve equation can be expressed as y=1.3451x+2.9759（R²=0.9978）,and the detection limit is 3.73 n M（S/N=3）.In addition,it shows good detection performance in anti-interference test,stability test and actual sample detection.