Study On Extraction Of Ibuprofen By Liquid Membrane

As a very typical nonsteroidal anti-inflammatory drug,ibuprofen（IBP）is widely used in clinical treatment.The long-term existence of IBP in wastewater not only poses a threat to human health,but also harms the balance of the ecosystem.In this paper,emulsion liquid membrane and ionic liquid supported liquid membrane were used to separate ibuprofen from aqueous solution,and their advantages were compared.Firstly,the conditions that affect the stability of emulsion liquid membrane were explored,and the best conditions for emulsion production were determined:kerosene was used as solvent,the mass fraction of surfactant（Z）-Mono-9-octadecenoic acid sorbitan ester（Span-80）was 5%,the mass fraction of membrane enhancer liquid paraffin was 3%,the mass fraction of carrier trioctylamine（TOA）was 5%,the concentration of internal NaOH was 0.1mol/L,and the oil to internal ratio was 1:1.The operating conditions are:stirring for 8 min at 720r/min,then ultrasonic for 6 min,the emulsion with high stability can be obtained.Optimizing various experimental factors of extracting ibuprofen by emulsion membrane,and determining the best conditions for extracting ibuprofen by emulsion membrane:the mass fraction of surfactant Span-80 was 5%,and the mass fraction of membrane enhancer liquid paraffin was 3%,the carrier TOA mass fraction was 5%,the internal phase NaOH concentration was 0.1mol/L,the oil to internal ratio was 1:1,the initial concentration of IBP was 250mg/L,the volume ratio of membrane to external phase was 1:3,and the speed was 220r/min.Under the conditions,the extraction rate can reach 95.3%.Finally,the ultrasonic-centrifugation method was used for demulsification,and the extraction rate of IBP was still above 80%after the emulsion was reused three times.PVDF and N66 ionic liquid supporting liquid membrane were prepared by dipping method,and characterized by scanning electron microscope（SEM）,photoelectron spectroscopy（XPS）and water contact angle technology.The experimental conditions for extracting ibuprofen were determined by designing a single factor experiment.The results showed that the PVDF ionic liquid supported liquid membrane had better mass transfer efficiency and extraction efficiency.The optimal experimental conditions were:the initial concentration of ibuprofen in the liquid phase was 180 mg/L,the concentration of NaOH in the analytical phase was 0.15mol/L,the extraction time was1.5h,the extraction temperature was 25℃,the liquid phase p H was 5,the stirring rate was 500r/min,the membrane immersion time was 24h,the mass fraction of[BMIM][PF₆]is 35%,and the membrane solvent was kerosene.Under the best experimental conditions,the extraction rate of ibuprofen can reach 96.7%.After 5 times of reuse,the extraction rate was still 90.1%.Both liquid membrane technologies can effectively separate ibuprofen in water.The emulsion liquid membrane method has the characteristics of short extraction time,simple operation and simple equipment requirements;the ionic liquid supported liquid membrane method has high extraction rate and high membrane stability,it can be reused many times.Both methods provide experimental basis for IBP industrial water treatment research,and have very important application value.