Preparation,drug Loading And Imaging Research Based On Mesoporous SiO₂@NaGdF₄:Yb³⁺,Er³⁺ Nanocomposites

Cancer is seriously threatening human health and life.This thesis proposes a multifunctional nanocomposite with imaging and drug loading functions Mesoporous SiO₂nanomaterials and NaGdF₄:Yb³⁺,Er³⁺.It can not only realize fluorescence imaging but also carry drugs.It will lay the experimental foundation for the ultimate realization of multi-modal diagnosis and treatment integration and the realization of early and accurate cancer diagnosis and treatment in the future.The main research contents are as follows:（1）The St（?）ber method was used to prepare and characterize silica with different morphologies（such as solid SiO₂,holmium-doped hollow mesoporous SiO₂,mesoporous SiO₂）.Among them,the influence mechanism of different ammonia water content on the morphology of solid SiO₂ was mainly studied.The influence mechanism of different template CTAB content on the morphology of mesoporous SiO₂ was studied.（2）PEG-modified NaGdF₄:Yb³⁺,Er³⁺nanomaterials were prepared by solvothermal method.XRD,TEM,FTIR and EDS energy spectroscopy were used to characterize this nanomaterial.After that,the effects of reaction conditions such as PEG content,reaction solvent,rare earth ion doping concentration and excitation power on the fluorescence properties of NaGdF₄:Yb³⁺,Er³⁺nanomaterials were studied.（3）NaGdF₄:Yb³⁺,Er³⁺and mesoporous SiO₂ composite nanomaterials prepared by hydrothermal method.The mesoporous SiO₂ and NaGdF₄:Yb³⁺,Er³⁺composite nanomaterials were characterized by TEM,XRD,FTIR and EDS energy spectroscopy.And research its drug loading and imaging.