Preparation Of Lactulose And Process Improvement Of Flecainide Acetate

The technological conditions for the production of lactulose and flecainide acetate were optimized and explored in this article.In order to quickly detect the content of lactulose in the isomerized liquid in the production of lactulose by isomerization of lactose,a method for detecting the content of lactulose was studied.A variety of catalytic methods for production of lactulose have been explored,and the hydrotalcite-like material as catalyst is the best method to produce lactulose.In addition,referring to the synthesis of flecainide acetate at home and abroad,a fast and efficient process for the preparation of flecainide acetate was developed.The specific research is divided into the following two parts:1.A new method was established to determine the content of lactulose.Lactulose solution and sulfuric acid will be acid hydrolyzed into galactose and fructose when heated in boiling water.Fructose will be converted into 5-hydroxymethyl furfural when heated under acidic conditions.Furfural has the maximum UV absorption at284 nm,using UV spectrophotometer method.It can quickly and accurately determine the content of lactulose in the isomerized liquid.On the other hand,the project uses this detection method to compare and study the improvement space of traditional alkaline method for producing lactulose.In addition,the lactulose detection method was used to determine that the calcined metal mixed oxides of hydrotalcite-like materials have a certain catalytic effect in the production of lactulose by the isomerization of lactose.At a substrate concentration of 0.5 mol/L,the addition amount is 15 mg/ m L,90℃ for 1.5 h to obtain lactulose conversion rate of 39%-43%.In the paper,we also selected the ondansetron drug to study the crystal form of the drug.And we expanded the crystal form research of the chiral drugs ondansetron and ondansetron hydrochloride.2.Starting from the commercial 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid,flecainide acetate can be easily obtained by acylating chlorination,neutralization reaction and complexing reaction.The overall yield is greater than 40%,which is similar to the yield reported in the literature,but the production time is greatly shortened and the production efficiency is significantly improved.At the same time,the route is simple to operate,and high-purity flecainide acetate can be prepared quickly and efficiently without a complicated purification process.