| Hydrogel has broad application prospects due to its flexibility,excellent biocompatibility and stimulus response ability.However,traditional hydrogels usually have some disadvantages,such as poor mechanical properties and single functions,which limit the further development of hydrogel applications.Therefore,how to design high strength and toughness hydrogels with multiple functions has become a hot spot for researchers.In this thesis,N-isopropylacrylamide hydrogel is the main research object and different metal-organic framework nanoparticles are used as filling materials to prepare different multifunctional and tough nanocomposites hydrogels with temperature response,drug release and sensing properties.The specific research content is as follows:1.The nanocomposite hydrogel with multifunctional and excellent mechanical properties were prepared by N-isopropyl acrylamide(NIPAM)and acrylamide(AAM)are used as hydrogel monomers and metal-organic framework material ZIF-8 as nano-fillers.The composite hydrogel exhibits high stretchability(elongation 808%),good fatigue resistance(It can withstand 10 uninterrupted stretches with a strain of500%.)and temperature response properties.Based on the high porosity of the ZIF-8material,the introduction of ZIF-8 nanoparticles not only improves the mechanical properties of the hydrogel,but also greatly improves the drug loading capacity of the composite hydrogel and the sustained drug release capability.In addition,the strain sensor based on the composite hydrogel can monitor various motions of human body in a wide strain range(10%-300%)in real time and reproducibly due to the good fatigue resistance and high tensile properties of the hydrogel,such as the bending of fingers and wrist joints.It can also be used for voice recognition.2.The 6,6’-dithiadinicotinic acid are used as the organic ligand and zirconium as the central metal to synthesize the metal-organic framework material Ui O-67.The nanocomposite hydrogel with multifunctional and excellent fatigue resistance was prepared by Ui O-67 nanoparticles as the nano-fillers,N-isopropylacrylamide(NIPAM)and acrylamide(AAM)are used as the hydrogel matrix.Compared with the ZIF-8composite hydrogel,the hydrogel shows more excellent drug sustained-release ability and anti-fatigue properties(It can withstand 20 uninterrupted stretches with a strain of500%.).In addition,Ui O-67 composite hydrogel also shows excellent freezing resistance.The hydrogel still exhibited good distortion,stretchability and electrical conductivity after being frozen in a refrigerator at-20 ~oC for 24 hours.The strain sensor based on the hydrogel shows more sensitive sensing performance.It not only can monitor human activities such as bending of fingers and wrist joints and speaking,but also monitor the pulse of the human body. |
