Study On The Nickel Catalyzed Decarbonylative Coupling Of Selenoester Via Activation Of C-C Bond

Diaryl selenium compounds and their derivatives are widely distributed in natural products and drug molecules.Therefore,the construction of diarylselenium compounds has become an important research area in organic chemistry.The carbonyl group,which is the core function group in ketone,aldehyde and carboxylic acid,is one of the most basic functional groups in organic compounds.The transition metal catalyzed cleavage and reconstruction of the carbon-carbon bond at theα-position of the carbonyl group has become an effective method for the rapid construction of complex molecules and an important strategy for transformation of carbonyl group.This method can be used to reorganize the molecular framework to construct specific organic molecules.However,the high orientation and high disconnecting energy within the C-C bond makes its activation and reconstruction procedure quite difficult and challenging.In recent years,great advance in study on the cleavage of carbon-carbon bonds at theα-position of carbonyl group has been achieved with the development of study on transition metal catalyzed reactions.In this paper,we report a nickel catalyzed-decarbonylative coupling reaction of selenoester.The cheap and easily available Ni Cl₂was employed as a catalyst in this reaction,and an efficient tool,which is based on the activation and reconstruction of the carbon-carbon bond at theα-position of the selenium ester carbonyl,for synthesis of various diarylselenium compounds is well developed.This reaction shows great functional group tolerance,high Chemoselectivity and good atom economy.The practical application of the reaction was also well studied;the syntheses of some functional molecules were reported in this paper.