Study On The Copper-catalyzed Cyanide Reaction Of Glycine Derivatives

This thesis is mainly divided into two parts.The first part briefly summarizes the research progress of cyanation reaction,which mainly includes the following two aspects:(1)research on the construction of C-C bond by cyanation reaction;(2)research on the X(X=N,O,S)-CN reaction.The second part details the research finding on the cyanation coupling reaction of glycine derivatives with TMSCN during the author’s graduate degree.The main contents are summarized as follows:The part details the catalytic oxidative C-H cyanation of glycine derivatives using a simple copper(I)catalyst with NFSI as an oxidant.The reaction undergoes a radical process to construct α-cyano glycine derivatives,Cu Cl acted as both a one-electron reductant and a transition-metal catalyst in this transformation.NFSI served as a one-electron oxidant and generated a N-centered radical as a H-abstractor,which are useful intermediates for organic synthesis.The key α-amino radical intermediates can be trapped by typical radical scavenger TEMPO.It is worth noting that the reaction displays mild reaction conditions and broad substrates scope,which could also feasibly be applied to a gram-scale synthesis.