| As functional molecules,organophosphine compounds are easy to modify in oxidation state,and have a wide range of applications in the fields of medicine,synthesis,materials,organic catalysts,etc.,especially as important ligands in metal’s complex catalysts（including chiral catalysts）.It is a great challenge to realize enantioselective synthesis through the late functionalization of phosphine derivatives,however transition metal-catalyzed functionalization provides a good idea for this direction,obviously C-H bond alkenylation is a simple and effective strategy,and provides a flexible and efficient way for the synthesis of phosphine ligands.In this paper,the research progress of phosphine oxide directed transition metal catalyzed C-H bond alkenylation and other functionalization of compounds was discussed.As well as the work carried out during my master’s degree: the reaction of Pd catalyzed C-H bond activation of N,N-diarylphosphoramides with cheap and easily available alkene substrates,finally successfully synthesized a series of monosubstituted alkenyl phosphine compounds.This method is simple and provides a new research method for asymmetric synthesis of axially chiral biarylphosphorene ligands. |
