Effects Of Altay Sheep Hips Oil Fractionated Products On Lipid Metabolism And Mechanism Studies

Because people are concerned about the health of animal fat,the resource-rich sheep hips fat has not been properly developed and applied,different fractionated products of fatty acid components obtained by fractionation technology,whether the fatty acid component difference of these products can be shown to affect the health of the body remains to be studied.Therefore,using Altay sheep hips oil and its fractionated products as the research materials,this experiment simulated the oil intake of some residents in China,compared and analyzed the effects of rapeseed oil,sheep hips oil and its fractionated products on lipid metabolism and its mechanism,and laid a biological foundation for the study of nutritional health of hips fat and its extraction products.The main results are as follows:(1)The short and long time intake of rapeseed oil,fractionated products increased the body weight of mice,but had no significant effect on the Lee’s index,BMI,liver index of mice(p>0.05).The intake of fractionated products in this experiment dose did not lead to obesity in mice.(2)The short time intake of sheep hips oil and rapeseed oil had no significant effect on the blood lipid level of mice(p>0.05),there was no significant effect on the level of blood lipid in mice after long-term intake of test oil(p>0.05).The duration of oil intake had no significant effect on the Total cholesterol,Triglyceride content and Arteriosclerosis index index in the plasma of mice(p>0.05),sheep hips oil,2℃ solid fractionated oil,32℃ solid fractionated oil could enhance the ability of liver catabolism and reduce liver lipid accumulation;12℃ solid fractionated oil,22℃ solid fractionated oil can regulate blood lipid metabolism by reducing LDL-C content.(3)The level of lipid in liver of sheep hips oil,2℃ solid fractionated oil,12℃ solid fractionated oil of mice.Moreover,12℃ solid fractionated oil were more effective than rapeseed oil and sheep hips oil in controlling hepatic lipid level.The intake of sheep hips oil or sheep hips oil fractionated products did not damage the liver function of mice,and the activity of 2℃ solid fractionated oil Alanine transaminase,Aspartate transaminase of sheep hips oil fractionated products was the lowest,and the effect of preventing hepatocyte injury was the best.Long-term intake of rapeseed oil has the risk Malondialdehyde elevated levels of lipid peroxidation,sheep hips oil effect of preventing liver oxidative damage is better than that of rapeseed oil,32℃ solid fractionated oil the effect of preventing liver oxidative damage is more prominent(p<0.05).(4)Short-term intake sheep hips oil,32℃ solid fractionated oil can significantly activate the relative expression of up-regulated Acyl-Co A Oxidase 1 genes in the liver,promote the oxidative decomposition of fatty acids and slow down the lipid deposition in the liver;Long time intake sheep hips oil,32℃ solid fractionated oil can effectively down-regulate the relative expression of Sterol-regulatory element binding protein-1c and Fatty acid synthetase,decrease the rate of fatty acid synthesis,and reduce liver lipid accumulation,and 32℃ solid fractionated oil better;Taking intake of 12℃ solid fractionated oil delayed liver lipid accumulation by reducing the relative expression of FAS genes.